Registration Dossier
Registration Dossier
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EC number: 209-952-3 | CAS number: 598-78-7
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
The American Conference of Governmental Industrial Hygienists accessed through the Toxnet website, which is a peer reviewed source, reports that 2 -chloropropionic acid failed to give a positive result in guinea pigs in a sensitisation test. In addition the IUCLID 4 dataset reports that the sodium salt of 2 -chloropropionic acid was tested in a guinea pig maximisation test according to OECD test guidleine 406. The study was carried out according to GLP. The study outcome was that the substance was not sensitising.
The available information constitutes an assessment of the available human and animal data.
Short description of key information:
The Toxnet website reports that 2-chloropropionic acid failed to give a positive result in guinea pigs in a sensitisation test. In addition, the sodium salt of 2-chloropropionic acid was not sensitising when tested in a guinea pig maximisation test according to OECD guideline 406.
Justification for classification or non-classification
Based on the available data the substance is considered to be not sensitising to skin.
No information is available with regard to respiratory sensitisation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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