Registration Dossier
Registration Dossier
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EC number: 231-212-3 | CAS number: 7447-41-8
Endpoint summary
Administrative data
Description of key information
Read-across from other Lithium compounds does not allow the conclusion that Lithium chloride may cause developmental/ teratogenic or reproductive effects in humans.
Additional information
As Lithium has been used in psychiatric therapy for the treatment of bipolar disorder for decades and Lithium chloride is also reported as drug to treat bipolar disorder, but rarely used compared to Lithium carbonate, most observations in humans are related to Lithium carbonate. The toxicity is most likely triggered by Lithium and not by carbonate or chloride as
- chloride is the most abundant anion in humans and all animal species and an essential element of the human body being responsible for metabolism,
- carbonate occurs ubiquitous and represents a physiological molecule.
Therefore, read-across from these reports to Lithium chloride is applicable.
This also applies for Lithium compounds that were not specified in the reports as they were administered for therapeutic reasons and are not expected to have a toxic counter ion. The reports on observations in humans did not allow conclusions that Lithium, resectively Lithium chloride
- may cause developmental/ teratogenic effects in humans (This is further supported by a recently performed study with Lithium carbonate in rats according to OECD 414, revealing no indication for a teratogenic potential of the Lithium salt. )
- is responsible for Ebstein's anomaly
- may impair male fertility (except the libido may be reduced due to treatment by a psychotropic drug).
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