Registration Dossier

Administrative data

Endpoint:
carcinogenicity: dermal
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
3 (not reliable)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1977

Materials and methods

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
mouse
Strain:
other: ICR-SLC
Sex:
female

Administration / exposure

Route of administration:
dermal
Vehicle:
other: benzene
Details on exposure:
Control group: 25 µl benzene/animal
Test group: 5µl o-chlorobenzotrichloride / animal
Duration of treatment / exposure:
30 weeks
Frequency of treatment:
Twice per week
Post exposure period:
18 months
No. of animals per sex per dose:
20
Positive control:
no data

Results and discussion

Applicant's summary and conclusion

Conclusions:
Despite of methodical weaknesses of this study a carcinogenic potential can not be excluded for the test item.
Thus o-chlorobenzotrichloride should be classified as R40, Limited evidence of a carcinogenic effect, or H351: Suspected of causing cancer, respectivly.
Executive summary:

According to the authors the tumor incidence for o-chlorobenzotrichloride was considerably lower than that for p-chlorobenzotrichloride but significantly increased in relation to the control group.