Registration Dossier
Registration Dossier
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EC number: 205-538-1 | CAS number: 142-47-2
Endpoint summary
Administrative data
Description of key information
Acute oral study (Publication, comparable to OECD guidelines for acute oral toxicity): Monosodium L-glutamate has been tested in a gavage study exposing 10 males and 10 females Wistar rat or ICR mouse to 21000 or 195000 mg/kg bw respectively. Rats or mouse which escaped from acute death showed no apparent change in body weight gains at one and two weeks after dosing, and no significant abnormalities were
observed in the gross findings of the visceral organs at the termination of the study. The LD50 was established to be > 2000 mg/kg bw.
Dermal acute toxicity (EEC-Directive 92/69 B.3, according to GLP principles):
Monosodium L-Glutamate monohydrate has been tested in a 24-hours, semi-occlusive study exposing 3 males and 3 females Wistar Crl: (WI)BR rat
to 2000 mg/kg bw. One female died on day2 and the following clinical signs were observed: Lethargy, hunched posture, piloerection, ptosis and or
chromodacryorrhoea on Days 1 and/or 2 (all animals). Focal erythema, scales and scabs of the treated skin between Days 1 and 8 (most animals).
The LD50 was established to be > 2000 mg/kg bw.
No data is available on acute inhalation toxicity.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Acute toxicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Additional information
Based on the studies performed, monosodium glutamate is not considered toxic via oral or dermal route, in acute toxicity tests.
Justification for classification or non-classification
Based on the information in the discussion mentioned above, the substance is not classified for acute toxicity according to DSD and CLP.
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