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EC number: 204-278-6 | CAS number: 118-79-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 985
- Report date:
- 1985
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- 2,4,6-tribromophenol
- EC Number:
- 204-278-6
- EC Name:
- 2,4,6-tribromophenol
- Cas Number:
- 118-79-6
- Molecular formula:
- C6H3Br3O
- IUPAC Name:
- 2,4,6-tribromophenol
- Test material form:
- solid: granular
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: Local strain of albino rabbits; not further specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: local strain obtained from A. Loebenstein Laboratory Animals, Yoqneam
- Age at study initiation: no information
- Weight at study initiation: 2.1 to 2.7 grams
- Housing: individual aluminum cages
- Diet (e.g. ad libitum): Commercially available complete pelleted rabbit diet (Arnavit), ad libitum
- Water: tap water, ad libitum
- Acclimation period: 7 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19 +/- 2 °C
- Humidity (%): 60% +/- 15%
- Air changes (per hr): 17
- Photoperiod (hrs dark / hrs light): 14 hours light per day
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- clipped
- Controls:
- no
- Amount / concentration applied:
- 500 mg
- Duration of treatment / exposure:
- 4h
- Observation period:
- 5, 24, 48 and 72 hours
- Number of animals:
- 6
- Details on study design:
- Single doses (0.5 g) of the test material were placed on to unmedicated gauze patches (25 x 25 mm) and were applied to the skin test site. The patch was held in place by a porous dressing strip which was then kept in place by an adhesive bandage to ensure that the test material was in close contact with the skin. The use of impervious material and occlusive dressing was to maximize the dermal absorption of the test material by the skin.
TEST SITE
- Area of exposure: Dorsum between the limb girdles
- % coverage: 25 x 25 mm
- Type of wrap if used: unmedicated gauze patches applied to skin and held in place by a porous dressing strip and adhesive bandage
REMOVAL OF TEST SUBSTANCE
- Washing (if done): gently wiped using double-distilled water to remove excess test material
- Time after start of exposure: 4 hours
SCORING SYSTEM: Criteria of Draize (1959) was used.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.16
- Reversibility:
- not fully reversible within: 24 h
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Irritant / corrosive response data:
- One rabbit had a very slight erythema 5 and 24 hours after dosing.
Animal No. Type of Score at time after dosing
and sex response 5 hrs 24 hrs 48 hrs 72 hrs
------------------------------------------------------------------------------------------
1 male E/O a) 0,0 0,0 0,0 0,0
2 male E/O a) 1,0 1,0 0,0 0,0
3 male E/O a) 0,0 0,0 0,0 0,0
1 female E/O a) 0,0 0,0 0,0 0,0
2 female E/O a) 0,0 0,0 0,0 0,0
3 female E/O a) 0,0 0,0 0,0 0,0
a) E/O: Erythema/Oedema (respectively)
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Under the conditions of this study, Tribromophenol is assessed as being a non-irritant material to the rabbit skin.
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