Registration Dossier
Registration Dossier
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EC number: 200-018-0 | CAS number: 50-21-5
Toxicity to reproduction
Administrative data
- Endpoint:
- reproductive toxicity, other
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1934
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Effects of feeding sodium bicarbonate or lactic acid upon the sex ratio in rats
- Author:
- D'Amour F.E.
- Year:
- 1 934
- Bibliographic source:
- Science 79 (2038), 61-62
Materials and methods
Test material
- Reference substance name:
- Lactic acid
- EC Number:
- 200-018-0
- EC Name:
- Lactic acid
- Cas Number:
- 50-21-5
- Molecular formula:
- C3H6O3
- IUPAC Name:
- 2-hydroxypropanoic acid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
Administration / exposure
- Route of administration:
- oral: feed
- Details on exposure:
- Animals to be bred were placed on stock diet, which consists of a mixture of ground grains, dried milk, mineral salts and cod liver oil, with which was incorporated with either sodium bicarbonate or lactic acid.
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- Prior to breeding to parturition
Doses / concentrationsopen allclose all
- Dose / conc.:
- 2.5 other: %
- Remarks:
- Percent of lactic acid in stock diet
- Dose / conc.:
- 5 other: %
- Remarks:
- Percent of lactic acid in stock diet
Results and discussion
Any other information on results incl. tables
Concentration |
# litters | Males | Females | Total |
| 2.5% lactic acid in feed | 10 | 38 | 42 | 80 |
| 5% lactic acid in feed | 28 | 107 | 128 | 235 |
| Total | 38 | 145 | 170 | 315 |
Sex ratio (females/males) = 170 /145 = 1.17
Applicant's summary and conclusion
- Conclusions:
- The sex ratio of the offspring was not affected by the treatment with lactic acid.
- Executive summary:
The sex ratio of the offspring was not affected by the treatment with lactic acid.
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