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Toxicological information

Basic toxicokinetics

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Administrative data

Endpoint:
basic toxicokinetics in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
other: abstract
Title:
Comparative pharmacokinetics and metabolism of ethylene glycol in pregnant rats and rabbits.
Author:
Carney, E.W., Pottenger, L.H., Bartels, M.J., Jaeckh, R., Quast, J.F.
Year:
1998
Bibliographic source:
Toxicology Letters 95, 208

Materials and methods

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent

Test animals

Species:
other: rat and rabbit
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
oral: gavage
Duration and frequency of treatment / exposure:
gd 10 rats and gd 9
Doses / concentrations
Remarks:
Doses / Concentrations:
500 or 2500 mg/kg

Results and discussion

Toxicokinetic / pharmacokinetic studies

Toxicokinetic parameters
Toxicokinetic parameters:
other: Key findings were: (1) maternal blood concentrations of EG were comparable in rats and rabbits; (2) levels of GA in maternal blood and EEF were 3 to 36-fold lower in rabbits than in rats; (3) in rats, concentrations of GA were higher in EEF than in matern

Applicant's summary and conclusion