Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-714-2 | CAS number: 109-87-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
Mutagenic data of methylal are shown in Table below. The only positive mutagenic effect was reported on 2 strains of S. typhimurium by Sam & Kruel (1989) whereas Kitching (1996) stated the negative genotoxicity of methylal. At more, negative results/predictions of Bacterial reverse mutation assay was denoted for methylal with Toxicity Prediction by Komputer Assisted Technology (TOPKAT), Deductive Estimation of Risk from Existing Knowledge (DEREK) for Windows (DfW) and CASETOX, 3 of the most widely used commercial toxicity prediction programs models fort the prediction of Ames test mutagenicity (White et al., 2003). In vitro mammalian chromosome aberration test and Micronucleus assay are both negative.
Test method (genotoxic endpoint measured) |
Positive result |
Negative result |
Reference |
Bacterial reverse mutation assay (gene mutation) |
Positive in S. typhimurium strains TA98, TA100 without activation |
Negative in S. typhimuriumstrains TA1535, TA1537, TA1538 with and without activation and strains TA98, TA100 with activation |
Sam & Kruel, 1989 |
Bacterial reverse mutation assay (gene mutation) |
None |
Negative in S. typhimuriumTA 1535, TA 1537, TA 98 and TA 100 with and without activation Negative inE. coliWP2 uvr A with and without activation |
Kitching, 1996 |
In vitro mammalian chromosome aberration test (chromosome aberration) |
None |
Negative in Chinese hamster ovary (CHO) with and without activation |
Young, 1990 |
Micronucleus assay (chromosome aberration) |
None |
Negative in mouse (in vivo) with and without activation |
Ivet, 1990 |
Short description of key information:
Only one positive result was obtained in bacterial reverse mutation assay with 2 strains of S. typhimuriums without activation. Other results were negative.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
According to CLP Regulation, methylal is not genotoxic and is not classified as mutagenic.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.