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Toxicological information

Skin sensitisation

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Administrative data

Endpoint:
skin sensitisation: in vivo (non-LLNA)
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Guideline study, performed under GLP conditions

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1997
Report Date:
1997

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 406 (Skin Sensitisation)
Version / remarks:
Also EC Guideline 96/54/EEC
GLP compliance:
yes (incl. certificate)
Type of study:
Buehler test

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent

In vivo test system

Test animals

Species:
guinea pig
Strain:
other: Hartley HsdPOC: DH
Sex:
female

Study design: in vivo (non-LLNA)

Inductionopen allclose all
Route:
epicutaneous, occlusive
Vehicle:
unchanged (no vehicle)
Concentration / amount:
0.5 ml
Challengeopen allclose all
Route:
epicutaneous, occlusive
Vehicle:
unchanged (no vehicle)
Concentration / amount:
0.5 ml
No. of animals per dose:
20
Positive control substance(s):
no

Results and discussion

In vivo (non-LLNA)

Resultsopen allclose all
Reading:
1st reading
Hours after challenge:
24
Group:
negative control
Dose level:
0.5 ml water
No. with + reactions:
0
Total no. in group:
10
Clinical observations:
No erythema or edema
Remarks on result:
other: Reading: 1st reading. . Hours after challenge: 24.0. Group: negative control. Dose level: 0.5 ml water. No with. + reactions: 0.0. Total no. in groups: 10.0. Clinical observations: No erythema or edema.
Reading:
2nd reading
Hours after challenge:
48
Group:
negative control
Dose level:
0.5 ml water
No. with + reactions:
0
Total no. in group:
10
Clinical observations:
No eythema or edema
Remarks on result:
other: Reading: 2nd reading. . Hours after challenge: 48.0. Group: negative control. Dose level: 0.5 ml water. No with. + reactions: 0.0. Total no. in groups: 10.0. Clinical observations: No eythema or edema.
Reading:
1st reading
Hours after challenge:
24
Group:
test group
Dose level:
0.5 ml
No. with + reactions:
0
Total no. in group:
20
Clinical observations:
no erythema or edema
Remarks on result:
other: Reading: 1st reading. . Hours after challenge: 24.0. Group: test group. Dose level: 0.5 ml. No with. + reactions: 0.0. Total no. in groups: 20.0. Clinical observations: no erythema or edema.
Reading:
2nd reading
Hours after challenge:
48
Group:
test group
Dose level:
0.5 ml
No. with + reactions:
0
Total no. in group:
20
Clinical observations:
No erythema or edema
Remarks on result:
other: Reading: 2nd reading. . Hours after challenge: 48.0. Group: test group. Dose level: 0.5 ml. No with. + reactions: 0.0. Total no. in groups: 20.0. Clinical observations: No erythema or edema.

Applicant's summary and conclusion

Interpretation of results:
not sensitising
Remarks:
Migrated information
Conclusions:
3-Cyanopyridine was tested in guinea pigs for sensitisation following occlusive dermal exposure. The substance was found to be non-sensitising.