Registration Dossier
Registration Dossier
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EC number: 202-863-0 | CAS number: 100-54-9
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation / corrosion
- Remarks:
- no data
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Reliable with restrictions; similar to Federal Register guidelines.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 991
- Report date:
- 1991
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: 52 FR 42964; U.S. Department of Transportation
- Principles of method if other than guideline:
- 52 FR 42964
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Nicotinonitrile
- EC Number:
- 202-863-0
- EC Name:
- Nicotinonitrile
- Cas Number:
- 100-54-9
- Molecular formula:
- C6H4N2
- IUPAC Name:
- pyridine-3-carbonitrile
- Reference substance name:
- Pyridine-3-carbonitrile
- IUPAC Name:
- Pyridine-3-carbonitrile
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- other: Albino
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- 0.5g at 3 test sites, corresponding to three exposure periods
- Duration of treatment / exposure:
- 3 minutes, 60 minutes, 4 hours
- Observation period:
- 48 hours
- Number of animals:
- 6
- Details on study design:
- After the initial reading, the test sites were washed with USP Sterile Water for Injection to prevent further exposure. After the exposure period, the patches were removed and the resulting reactions scored for erythema, edema and/or corrosion. Readings were made again at the end of 48 hours.
Results and discussion
In vivo
Results
- Irritation parameter:
- other: qualitative assessment of corrosion
- Basis:
- mean
- Time point:
- other: 48 h
- Remarks on result:
- other: qualitative assessment for skin corrosion
- Irritant / corrosive response data:
- None of the animals exhibited any signs of skin corrosion at any of the test sites.
Any other information on results incl. tables
This is a qualitative test according to U.S. Department of Transportation guidelines. None of the animals exhibited any signs of skin corrosion at any of the test sites.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: other: U.S. Department of Transportation guidelines
- Conclusions:
- 3-Cyanopyridine is not considered corrosive to the skin of albino rabbits after occlusive dermal exposure for 3 min, 1 hour and 4 hours.
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