Registration Dossier
Registration Dossier
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EC number: 202-863-0 | CAS number: 100-54-9
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Reliable with restrictions; comparable to guideline study with acceptable restrictions.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 973
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: no information on method
- Principles of method if other than guideline:
- no information on method
- GLP compliance:
- no
- Test type:
- other: LD50
- Limit test:
- no
Test material
- Reference substance name:
- Nicotinonitrile
- EC Number:
- 202-863-0
- EC Name:
- Nicotinonitrile
- Cas Number:
- 100-54-9
- Molecular formula:
- C6H4N2
- IUPAC Name:
- pyridine-3-carbonitrile
- Reference substance name:
- Pyridine-3-carbonitrile
- IUPAC Name:
- Pyridine-3-carbonitrile
- Details on test material:
- Purity of Nicotinonitrile: not stated
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- other: Sherman-Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- Rats weighed 200-300g
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- Rats were deprived of food, but not water, for 24 hours prior to dosing. Food and water were available ad libitum post dose.
- Doses:
- Concentrations of 250, 500, 1000, 2000 and 4000 mg/kg.
- No. of animals per sex per dose:
- Five male rats per group were dosed at 50% w/v suspension in water
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 1 100 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 960 - 1 500
- Mortality:
- 250 mg/kg = 0/5
500 mg/kg = 0/5
1000 mg/kg = 2/5 — within 24 hours, animals were semi-comatose, which prevaled for five days during which time two animals died, one at three days post dose and the other four days post dose.
2000 mg/kg = 5/5
4000 mg/kg = 5/5 - Clinical signs:
- other: No signs of toxicity were observed at the 250 mg/kg dose level. At 500 mg/kg, the rats were depressed one hour post dose and lethargic. They appeared normal 24 hours post dose.
- Gross pathology:
- Findings revealed nothing remarkable.
- Other findings:
- Rats in the 1000 mg/kg dose group were extremely depressed 30 minutes post dose and exhibited shallow breathing. Within 24 hours they were semi-comatose. The surviving rats appeared normal eight to nine days post dose. At 2000 mg/kg and 4000 mg/kg the animals died within 1-3 hours.
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category IV
- Remarks:
- Migrated information LD50 > 300 mg/kg and < 2000 mg/kg Criteria used for interpretation of results: EU
- Conclusions:
- The acute oral LD50 of 3-cyanopyridine has been adequately characterized at 1100 mg/kg (95% Confidence limits = 960-1500 mg/kg)
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