Registration Dossier
Registration Dossier
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EC number: 428-200-7 | CAS number: 103577-66-8
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 001
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion)
Test material
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #1
- Time point:
- other:
- Score:
- 1.6
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #2
- Time point:
- other:
- Score:
- 1.6
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #3
- Time point:
- other:
- Score:
- 1
- Max. score:
- 2
- Reversibility:
- fully reversible
- Remarks on result:
- other:
- Irritation parameter:
- chemosis score
- Basis:
- animal #1
- Time point:
- other:
- Score:
- 0
- Irritation parameter:
- chemosis score
- Basis:
- animal #2
- Time point:
- other:
- Score:
- 0.3
- Irritation parameter:
- chemosis score
- Basis:
- animal #3
- Time point:
- other:
- Score:
- 0.3
- Max. score:
- 1
- Reversibility:
- fully reversible
- Remarks on result:
- other:
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #1
- Time point:
- other:
- Score:
- 0
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #2
- Time point:
- other:
- Score:
- 0.3
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #3
- Time point:
- other:
- Score:
- 0
- Max. score:
- 1
- Reversibility:
- fully reversible
- Remarks on result:
- other:
- Irritation parameter:
- iris score
- Basis:
- animal #1
- Time point:
- other:
- Score:
- 0
- Irritation parameter:
- iris score
- Basis:
- animal #2
- Time point:
- other:
- Score:
- 0
- Irritation parameter:
- iris score
- Basis:
- animal #3
- Time point:
- other:
- Score:
- 0.3
- Max. score:
- 1
- Reversibility:
- fully reversible
- Remarks on result:
- other:
Applicant's summary and conclusion
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