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EC number: 406-640-0 | CAS number: 136920-07-5 KEROFLUX ES 3241
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Additional information:
A guinea pig maximization test was performed comparable to OECD guideline 406 and according to GLP requirements (BASF AG 1991). 10 Dunkin Hartley guinea pigs were used in the treatment group and 5 test animals were used in the control groups (a second control group for a second challenge was not needed due to unambiguous results of the first challenge). Based on a pretest, following concentrations for induction and the challenge were selected:
Intradermal induction: 5% in olive oil DAB 9 or FCA
Percutaneous induction: 50% in olive oil DAB 9
Percutaneous Challenge: 25% in olive oil DAB 9
Following effects were observed: After intradermal induction well-defined erythema and slight edema were observed at the injection sites of the control and test animals, at which only Freund's adjuvant/0.9% aqueous NaCl-solution (1:1) was applied. Injection of the test substance in olive oil DAB 9 resp. in Freund's adjuvant/0.9% aqueous NaCl-solution (1:1) caused well-defined derythema and slight edema in the test animals. The control animals injected with olive oil DAB 9 (vehicle) showed well-defined erythema. After percutaneous induction incrustation partially open (caused by the intradermal induction) in addition to well-defined erythema and slight edema were observed in the test and control animals.
After the challenge with the 25% test substance preparation in olive oil DAB 9 six out of nine test animals showed very slight erythema. The animals of control group 1 did not show any skin reactions. Olive oil DAB 9 applied as a vehicle did not cause any skin reactions neither in the test animals nor in the animals of control groups 1 and 2. Keroflux ES 3241 has therefore to be considered as skin sensitiser.
Migrated from Short description of key information:
Guinea Pig Maximization Test: sensitising (GLP, comp. to OECD 406; BASF AG 1991)
Respiratory sensitisation
Endpoint conclusion
- Additional information:
no data
Migrated from Short description of key information:
no data
Justification for classification or non-classification
Following the conditions and results of the available test, Keroflux Es 3241 has to be classified with R43 and skin sensitising Cat. 1 according to EEC/67/548 and UN-GHS requirements, respectively.
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