Registration Dossier

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2000

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: 92/69/EWG, B.4
GLP compliance:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
other: rbt, New Zealand White Crl:KBL

Test system

Type of coverage:
semiocclusive
Vehicle:
other: Aqua
Amount / concentration applied:
500 mg
Duration of treatment / exposure:
4 h
Number of animals:
1

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Basis:
animal #1
Remarks:
(mean score 1)
Time point:
other: overall at 24, 48 and 72 h
Score:
> 3
Irritation parameter:
erythema score
Max. score:
4
Remarks on result:
other: Max. duration: 4 d; Max. value at end of observation period: 4 (related to all animals)
Other effects:
Nekrose an der Applikationsstelle nach 4 h.

"ENGLISH"

Necrosis was seen at the site of application after 4 h.

Applicant's summary and conclusion

Executive summary:

The substance was found to be corrosive (Cat 1 B).