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EC number: 447-010-5 | CAS number: 670241-72-2
Litter data at birth and on Day 4 post-partum - Group mean data
On Day 4
Live litter size
Pup loss %
Litter wt (g)
Mean pup wt (g)
Cumulative loss %
Litter wt. (g)
Mean pup wt. (g)
* = Statistically significantly different from control group value at p < 0.05
The effects on reproduction and development of the offspring were evaluated after oral administration of BENZOIC ACID ISONONYLESTER in male and female rats. The test item was given before and during mating and throughout the gestation period until Day 3 post-partum at dosages of 100, 300 and 1000 mglkg/day. Body weight, body weight gain and food consumption were not affected by treatment in male or female animals. Reproductive parameters such as fertility index, pre-coital interval and copulatory index did not show significant differences in treated groups compared to controls. A slight reduction in mean pup weight and consequently in litter weight was noted in group 4 females at birth and on Day 4 post-partum. The histopathological examination of the ovaries, testes (including the stage in the spermatogenic cycle) did not reveal any evident differences between the findings observed in the treated and control animals. On the basis of the results, the dosage of 1000 mg/kg/day could be considered as the NOAEL.
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