Registration Dossier
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EC number: 420-310-3 | CAS number: -
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 995
- Report date:
- 1995
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion)
- Deviations:
- no
Test material
- Test material form:
- solid: particulate/powder
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other:
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other:
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other:
- Score:
- 0
- Max. score:
- 2
- Remarks on result:
- other:
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other:
- Score:
- 0.33
- Max. score:
- 3
- Reversibility:
- fully reversible within:
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other:
- Score:
- 0
- Max. score:
- 3
- Reversibility:
- fully reversible within:
- Remarks on result:
- other:
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- other:
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other:
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- other:
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible within:
- Remarks on result:
- other:
Applicant's summary and conclusion
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