Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 700-184-9 | CAS number: 1000172-11-1
Endpoint summary
Administrative data
Description of key information
No data available on substance. See discussion for data on analogues
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
There is no data available measured on the test substance itself " Pentadecane, 7-methylene mixed with 1-tetradecene, dimers and trimers, hydrogenated", which is a C28 -80H58 -162 saturated branched alphaolefin oligomer of number average molecular weight 443 (Mw=448) but data is available on four alphaolefin analogues based on oligomerised and hydrogenated 1-decene. These span a number average molecular weight of 287 -603 and whilst linear rather than branched are likely to behave similarly for these end points.
SKIN IRRITANCY
The table below indicates the results from the analogue substances:
| Analogue Mn | Primary skin irritation index | Max irritation score (erythema) |
Classification |
| 287 | 3.1 | 3 | Irritant |
| 443 | 1.3 | 3 | Not irritant |
| 528 | 0.5 | 2 | Not irritant |
| 603 | 0.5 | 1 | Not irritant |
There is a clear trend of decreasing irritancy potential with molecular weight increase. Based on these results, the closest analogue is the one with similar molecular weight which would suggest that the dossier substance would be a mild skin irritant only. Quantitatively, these results involved using 0.5ml over one square inch of skin (6.25cm2), which is approximately 65mg/cm2. This can be deemed a NOAEL for skin irritation.
EYE IRRITANCY
The table below indicates the results from the analogue substances:
| Analogue Mn | Overall irritation score(Average of 24, 48, 72hrobservations) | Maximum score in any one animal at any time point |
Classification |
| 287 | 2 | 6 | Not irritant |
| 443 | 1.8 | 4 | Not irritant |
| 528 | 0.33 | 2 | Not irritant |
| 603 | 1.4 | 4 | Not irritant |
Note: overall irritation score = (Degree of corneal opacityxareax5)+(Iris scorex5)+(erythema score+conjunctival score+swelling)x5. Maximum possible score is 110. Maximum score is maximum overall irritation score seen in any one animal.
No substance caused corneal effects or iritis. There was no clear trend with molecular weight, although there is some suggestion that the lowest molecular weight oligomer is slightly more irritating. Overall, the substances show very low irritating potential.
Based on these results, the closest analogue is the one with similar molecular weight which would suggest that it would be a mild eye irritant only.
RESPIRATORY IRRITATION
There is no data available but the results for skin and eye irritancy indicate a very low respiratory irritation potential
Justification for classification or non-classification
SKIN IRRITATION: Based on the data available from read across substances, the substance of interest is not likely to meet the criteria as a skin irritant either from the perspective of acute effects or time for them to disappear.
EYE IRRITATION: Based on the data available from read across substances, the substance of interest is not likely to meet the criteria as a eye irritant either from the perspective of acute effects or time for them to disappear.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
