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EC number: 700-184-9 | CAS number: 1000172-11-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 21 DEC 2005 to 4 JAN 2006
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study in accordance with OECD Procedure No. 402 (1987) and US EPA OPPTS 870.1200 (1998), and complying with principles of GLP (OECD and EPA).
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 006
- Report date:
- 2006
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.1200 (Acute Dermal Toxicity)
- Deviations:
- no
- GLP compliance:
- yes
- Remarks:
- Quality assurance statement for adherence to GLP
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 883233-48-5
- EC Number:
- 618-141-7
- Cas Number:
- 883233-48-5
- IUPAC Name:
- 883233-48-5
- Reference substance name:
- 1-tetradecene polymer with 1-dodecene, distn residues, hydrogenated, C24-56 fraction
- IUPAC Name:
- 1-tetradecene polymer with 1-dodecene, distn residues, hydrogenated, C24-56 fraction
- Details on test material:
- Lot No. 200-346
Specific gravity: 0.824 g/ml.
Physical state: Clear liquid soluble in corn and mineral oil.
Test substance was expected to be stable for the duration of testing
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Ace Animals, Inc., Boyertown, PA on December 6, 2005
- Age at study initiation: 9-10 weeks
- Weight at study initiation: 295-307g (males) and 215-238g (females)
- Fasting period before study: No data
- Housing: Singly housed in suspended stainless steel caging with mesh floors. Litter paper placed beneath cage and changed at least 3 times per week.
- Diet: Purina Rodent Chow #5012
- Water: Filtered tap water ad libitum by automatic water dispensing system
- Acclimation period: 15 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19-22
- Humidity (%): No data
- Air changes (per hr): No data
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From: 21/12/2005 To: 22/12/2005
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: The dorsal area and the trunk of animals was clipped (Oster model #A5-small) on the day prior to application. Test substance was applied evenly over a dose area of approximately 2 inches x 3 inches.
- % coverage: approximately 10% of the body surface
- Type of wrap if used: 2-inch x 3-inch, 4-ply gauze pad. The gauze pad and entire trunk of each animal were then wrapped with 3-inch Durapore tape.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): pads removed and test sites gently cleansed
- Time after start of exposure: 24 hours
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.52 ml to 0.75 ml
- Concentration (if solution): Specific gravity - 0.823 g/ml (determined by testing laboratory)
- Constant volume or concentration used: constant concentration - Duration of exposure:
- 24 hours
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
- Details on study design:
- - Selection of animals: After clipping and prior to application, the animals were examined for health, weighed (initial) and the skin checked for any abnormalities. Ten healthy rats (five males and five females) were selected for test.
- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Animals were observed for mortality, signs of gross toxicity, and behavioural changes during the first several hours after application and at least once daily thereafter for 14 days. Individual body weights recorded prior to test substance application (initial) and again on Days 7 and 14 (termination).
- Necropsy of survivors performed: yes.
- Other examinations performed: Observations included gross evaluation of skin and fur, eyes and mucous membranes, respiratory, circulatory, autonomic and central nervous systems, somatomotor activity and behaviour pattern. Particular attention was directed to observation of tremors, convulsions, salivation, diarrhoea, and coma. - Statistics:
- No data
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- No deaths occurred
- Clinical signs:
- other: All animals survived, gained body weight, and appeared active and healthy during the study. There were no signs of gross toxicity, dermal irritation, adverse pharmacological effects, or abnormal behaviour.
- Gross pathology:
- No gross abnormalities were noted for any of the animals when necropsied at the conclusion of the 14-day observation period.
- Other findings:
- No data.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Substance has no significant acute toxicity by the dermal route.
- Executive summary:
An acute dermal toxicity test was conducted with rats to determine the potential for a C24 -C56 hydrogenated polyalphaolefin to produce toxicity from a single topical application. Under the conditions of this study, the single dose acute dermal LD50 of the test substance is greater than 2000 mg/kg body weight in male and female rats. The study was conducted according to current OECD and EPA guidelines and is compliant with GLP standards. Based on the results of this study, this substance would not be classified for acute dermal toxicity in accordance with the current EU guidelines and the EU GHS classification regulation.
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