Registration Dossier
Registration Dossier
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EC number: 423-870-7 | CAS number: -
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2002-02-22 to 2002-04-16
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Remarks:
- preliminary estimation, duration and speed of centrifugation and purity of the test item are missing; temperature was not kept constant ±1°C
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- Version / remarks:
- , 1995
- Deviations:
- yes
- Remarks:
- , please refer to the field "Rationale for reliability incl. deficiencies" above
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- Version / remarks:
- 92/69/EEC (1992)
- Deviations:
- yes
- Remarks:
- , please refer to the field "Rationale for reliability incl. deficiencies" above
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- , signed 1999-05-25
- Type of method:
- shake-flask method to: flask method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Type:
- log Pow
- Partition coefficient:
- <= -2
- Temp.:
- 20.6 °C
- pH:
- >= 6.29 - <= 6.43
- Remarks on result:
- other: a log Pow of -3.4103 was determined (n=6)
- Details on results:
- LOD: 0.04 mg/L
LOQ: 0.1 mg/L - Conclusions:
- The log Pow of the test item was estimated≤ -2 at 20.6 °C and pH 6.29 - 6.43.
Reference
No concentration of the test item in the n-octanol phase was determined. A concentration of 0.1 mg/L (LOQ) was assumed. With this assumption an log Pow of -3,4103 ± 2.57*10-3 was calculated.
The shake flask method is only suitable for a log Pow ≥ -2. Therefore a log Pow of < -2 for the test item was assumed.
The solubility of the test item in n-octanol is lower (minimum a hundred times) than in water.; even if the assumption (0.1 mg/L in n-octanol) is wrong, the Pow can not be >0. The Pow is important for the estimation of a bioaccumulation potential. A more exactly determination is therefore not necessary.
Description of key information
The log Pow of the test item was estimated ≤ -2 at 20.6 °C and pH 6.29 - 6.43.
Key value for chemical safety assessment
Additional information
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