Registration Dossier

Administrative data

Key value for chemical safety assessment

Effects on fertility

Description of key information

FC-770 was not toxic to reproduction or developmental effects via oral gavage when tested at concentrations up to 1000 mg/kg-day.

Additional information

Animals were dosed at 100, 500 and 1000 mg/kg-day under OECD Guideline 421.Group mean body weight gains and food consumption in the males throughout the study, and for females during gestation and lactation were similar to control. Mating performance, fertility, duration of gestation, litter size and survival, and litter and pup weights did not indicate any obvious effect of treatment at any of the dose levels tested. CONCLUSION: Based on the results of this study, the no observed effect level (NOEL) for adults and for reproductive parameters was considered to be 1000 mg/kg-day.

Justification for classification or non-classification

The results of these tests do not meet the requirement to classifyFC-770 as Toxic for Reproduction.