Registration Dossier

Administrative data

First-aid measures

Emergency measure - Inhalation: Move promptly to fresh air. If appropriate rinse mouth and
nose thoroughly with water. If breathing stops administer
artificial respiration. Administer oxygen if breathing is
difficult. Obtain medical advice immediately.
Emergency measure - Eyes: Wash out with water or saline solution for at least 15
minutes, including under eyelids. If persistant irritation
is present seek medical advice.
Emergency measure - Skin: Remove contaminated clothing and wash affected skin with
soap and water. If adverse reaction occurs or persists seek
medical advice.
Emergency measure - Ingestion: Rinse mouth with water. Do not induce vomiting. Seek
medical attention immediately.

Fire-fighting measures

Recommended extinguishing agent: Dry powder, foam, carbon dioxide

Product arising from burning: None known, however incomplete combustion may produce
harmful oxides of carbon and nitrogen

Product determined by test: N

Protective equipment: Wear self contained breathing apparatus and protective suit.

Accidental release measures

Emergency measures in case of spillage: Wear suitable protective clothing to minimise contact with
skin or eyes and respiratory protection to prevent
inhalation. Contain the spillage, sweep up, place in bag and
hold for waste diposal. Avoid raising dust and wash spill
site after material pick up is complete. Avoid discharge to
drains/surface water.

Handling and storage

Handling: (S)-AMI.HCl is handled in two operations only- sampling and
dispensing to IBCs. Both operations are conducted inside
downflow booths designed for the specific operation.


Sampling: The sampling booth is a stand-alone unit located
in the warehouse, consisting of two separate "rooms" - an
inner sampling area, and an airlock through which personnel
ans materials for sampling must pass. Air is extracted by a
fan from the inner sampling area, and recircilated through
a pre-filter and HEPA filter back into the sampling area
(90%) and airlock (10%). Local gauges are fitted in the
sampling area, allowing the operator to monitor the booth
operation condition:

- sampling area pre-filter and HEPA differential pressures
(Dp)

- airlock pre-filter and HEPA differential pressures (Dp)

- Dp between sampling area and airlock

- Dp between airlock and warehouse

- airflow through sampling area


Dispensing: The dispensing booth is a downflow booth located
in a dedicated dispensing room. This room is separarted
from the main production facility by two airlocks - one for
personnel entry and one for materials entry. The booth is
open to the dispensing room on one side, but airflow pattern
is designed to provide containment within a defined safe
working area. There is a 10% bleed of filtered exhaust air
back to the dispensing room, and 10% make-up of fresh air
supply from the room to the booth. Local gauges are fitted
at the booth entrance, allowing the operator to monitor the
booth operating condition:

- coarse dust, fine dust and HEPA filter differential
pressures

- booth airflow


Appropriate personal protective equipment to be worn when
handling (S)-AMI.HCl:


Respiratory protection - dust mask or full-face respirator
(EN 136)

Hand protection - disposable nitrile gloves (EN 374-2-374-3)

Eye protection - goggles (EN 166)

Skin protection - disposable, impermeable outer garments
including boot covers and hat (EN 340/EN 365)

Storage: Keep tightly closed in a cool, dry and well ventilated
place. Keep away from heat and sources of ignition. Store
in original container.

Packaging of the substance and or preparation: Substance is packaged in 50kg fibre drums (net fill weight
30kg of substance per drum) within double polyethlyene bag
with tamperproof lids.

Transport information

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Marine transport (IMDG)

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Air transport ICAO/IATA

Remarks
Transport code: UN3077
Transport: Transport in sealed, unbreakable containers secured against
falling or other shock.
SpecialProvisionsopen allclose all

Exposure controls / personal protection

Stability and reactivity

Danger other than fire: None known.

Chemical reaction with water: None known.

Dust explosion: Dust cloud ignition at 440 degrees C.


No ignition for 5mm dust layer, which melts over approx. 200
degrees C.


Miniumum ignition energy of dust/air mixture was 1-10J.

Dust explosion determined by test: Y

Disposal considerations

Industry - Possibility of recovery/recycling: Not applicable

Industry - Possibility of neutralisation: Neutralisation is not necessary

Industry - Possibility of destruction: controlled discharge: Not recommended

Industry - Possibility of destruction - incineration: Recommended

Industry - Possibility of destruction - water purification: Not recommended

Industry - Possibility of destruction - other: Not recommended

Public at large - Possibility of recovery/recycling: Not applicable: no sale to consumers will occur

Public at large - Possibility of neutralisation: Not applicable: no sale to consumers will occur

Public at large - Possibility of destruction: controlled discharge: Not applicable: no sale to consumers will occur

Public at large - Possibility of destruction - incineration: Not applicable: no sale to consumers will occur

Public at large - Possibility of destruction - water purification: Not applicable: no sale to consumers will occur

Public at large - Possibility of destruction - others: Not applicable: no sale to consumers will occur