Registration Dossier
Registration Dossier
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EC number: 607-988-8 | CAS number: 2668-75-9
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
The substance was examined for mutagenic activity in the Ames Salmonella/microsome test with the five histidine-dependent Salmonella typhimurium strains TA 1535, TA 100, TA 1537, TA 1538 and TA 98, all with and without metabolic activation. E. coli WP2 or S. typhimurium TA102 strains were not investigated. The test substance concentration ranged from 0.1 to 5.0 mg/plate.
Growth inhibition of the background lawn was observed in all strains tested from 1.0 mg/plate onwards in the absence of S9 mix and at the highest dose tested with S9 mix.Precipitates in the agar were found starting from 2.5 mg/plate onwards in all strains tested without and with S9 mix.None of the tester strains showed an increase in mutant counts with the substance at the concentrations tested, either in the absence or presence of S9 mix. It was therefore concluded, that the substance is not a mutagen in the specified test.
Short description of key information:
Gene mutation (bacterial reverse mutation assay, OECD TG471, no E. coli WP2 or S. typhimurium TA102 strain investigated): negative with and without metabolic activation
[Schering AG, Report No. X203 -draft-, 1998-01-08]
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
Based on the results there is no classification required according to Directive 67/548/EEC or Regulation (EC) 1272/2008 (CLP).
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