Pregna-1,4-diene-3,20-dione, 6-fluoro-11-hydroxy-16-methyl-21-[(1-oxopentyl)oxy]-, (6.alpha.,11.beta.,16.alpha.)-

Flammability

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

flammable solids

Type of information:

experimental study

Adequacy of study:

key study

Study period:

14 Dec 2015 to 06 Apr 2016

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

test procedure in accordance with national standard methods with acceptable restrictions

Qualifier:

according to guideline

Guideline:

UN Manual of Tests and Criteria: Test N.1 (Test method for readily combustible solids)

Deviations:

no

GLP compliance:

no

Other quality assurance:

ISO/IEC 17025 (General requirements for the competence of testing and calibration laboratories)

Key result

Test procedure:

burning rate test: preliminary screening test

Remarks on result:

substance does not ignite and propagate combustion either by burning with flame or smouldering along 200 mm of the powder train within the 2 minutes test period

The substance in its delivery state was measured. The test substance melted when approached by the ignition flame. The substance did not burn up. No further testing was required.

 

Validity criteria for the measurement of the flammability:

Target condition according to guideline 92/69/EWG A. 12:	Actual condition according to the study:	Validity criteria met:
The report shall include the results of the tests (steps 1, 2, 3 and 4) and the chemical identity of gas evolved.	The results of the steps are stated. No gas evolution occured.	Yes
The rate of evolution of gas if step 4 is performed shall be stated.	No gas evolution occured.	Yes

Interpretation of results:

not classified based on GHS criteria

Conclusions:

Fluocortolon-21-valerat is in the sense of the CLP-Directive a not flammable solid.

Executive summary:

Fluocortolon-21 -valerat is classified as a not readily combustible solid when tested according to UN-MTC Procedure N.1. Fluocortolon-21 -valerat is in the sense of the CLP-Directive a not flammable solid. The test was performed as stipulated in UN test procedure ‘Recommendations on the Transport of Dangerous Goods-Manual of Tests and Criteria’ (UN-MTC), Part III, sub-section 33.2.1.4.1, Test N.1 ‘Test method for readily combustible solids’.

Reference 2

Endpoint:

self-heating substances / mixtures

Type of information:

experimental study

Adequacy of study:

key study

Study period:

09 Feb to 25 May 2018

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

test procedure in accordance with national standard methods

Qualifier:

according to guideline

Guideline:

other: German standard method "VDI 2263, Part 1 ‘Test Methods for the Determination of the Safety Characteristic of Dusts’"

GLP compliance:

no

Other quality assurance:

ISO/IEC 17025 (General requirements for the competence of testing and calibration laboratories)

Test procedure:

other: Grewer oven test

Result:

negative outcome (no effect observed)

The wire mesh basket was empty after the measurement.

Interpretation of results:

not classified based on GHS criteria

Conclusions:

Fluocortolon-21-Valerat is not a self-heating substance in the sense of CLP Annex I, 2.11.

Executive summary:

Appendix 6, point 5.2.2 of UN-MTC test procedure refers to the Grewer oven test. The test was performed as stipulated in test procedure VDI 2263, Part 1 ‘Test Methods for the Determination of the Safety Characteristic of Dusts’.

The sample in its delivery state and an inert reference sample are heated up to 410 °C at a rate of 0.5 K/min in an air flow of about 20 L/h.

No exothermic effects were determined up to the point at which the test substance melted. The wire mesh basket was empty after the measurement.

‘Fluocortolon-21-Valerat, ger.' is not a self-heating substance in the sense of CLP Annex I, 2.11. The determination according to UN-MTC Procedure N.4 (Bowes-Cameron-Cage-Test) is not necessary.

Description of key information

a) Flammability: Fluocortolon-21-valerat is classified as a not readily combustible solid according to UN-MTC Procedure N.1.

b) Self-heating substances: Fluocortolon-21-valerat is not a self-heating substance in the sense of CLP Annex I, 2.11.

c) Pyrophoric properties: Fluocortolon-21-valerat did not deliver indications of pyrophoric properties during the realization of other tests. The determination according to UN-MTC Procedure N.2 is not necessary.

d) Contact with water: A review of the structure suggests that there are no chemical groups present that would imply pyrophoric properties or flammability on contact with water. A review of handling and use implies no pyrophoric properties or flammability on contact with water. Testing according to UN Procedure N.5 is not necessary.

Key value for chemical safety assessment

Flammability:

not classified