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EC number: 448-020-2 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- from 2000-01-25 into 2000-02-08
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
- Year:
- 2 000
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: 92/69/EEC, B.1 Acute toxicity (oral). OECD Guideline No. 401
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
Reference
- Name:
- Unnamed
- Type:
- Constituent
- Details on test material:
- Test batch no.: 7/99
Test animals
- Species:
- other: rat - Wistar
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Wistar
- Housing: cage T4, 5 rats per cage per sex
- Diet (e.g. ad libitum): standart food ST-1/ Bergman, mlýn Koccanda
- Water (e.g. ad libitum): ad libidum
- Acclimation period: 1 week
-12 hours light / 12 hours dark
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: The sample was applied in delivered form "as is" tempered at 20-C.
- Details on oral exposure:
- Tested substance was administrated by gavage directly into stomak once.
- Doses:
- 2000 mg/kg
- No. of animals per sex per dose:
- Male dose: 2000 mg/kg nr. of animals: 5
Female 2000 mg/kg 5 - Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- 95% CL:
- ca. 95
- Mortality:
- Male: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0 - Clinical signs:
- Signs of toxicity related to dose levels: Males: The clinical symptoms of intoxication were observed in four animals- from the 4th to the 7th day, in one animal until eighth day after administration. The animals had motional distresses, the distresses in reaction to impulses,the easy effluences from the eyes and nostrils were detected, the intake of food was delimited and the exaggeration was also detected. On the 9th day after application the visible symptoms of health disorder were finished. No animal was died. Female: Negative impact of tested substance was not so strong in the female group. Moderate health disorders were observed in four animals from the 4th to the 6th day and in one animal until 7th day after the application. The animals showed the decreased reactions to the impulses, their breathing was slow and they did not accept the food. No visible clinical symptoms of intoxication were observed on the 8th day after application. No animal died.
- Body weight:
- Body weight was observed at the begining and at the end of test . Weight increase or decrease was calculated from difference.
- Gross pathology:
- Effects on organs: During the test no toxic expose was observed. After 14-days of testing period the surviving animals (from the male group) were killed and disemboweled. The morbid- anatomical diagnosis was negative four animals without any change, one animal was partially peaked with liver hyperemis. For the female group the morbid-anatomical diagnosis was negative only for one animal the liver repletion was registered.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
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