imidacloprid (ISO); 1-(6-chloropyridin-3-ylmethyl)-N-nitroimidazolidin-2-ylidenamine

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1-12 Feb 1993

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Deviations:

yes

Remarks:

adjustment of the solution equilibrium as in CIPAC MT 157 part 2

Qualifier:

according to guideline

Guideline:

other: CIPAC method MT 157, Part 2

GLP compliance:

yes

Type of method:

column elution method

Water solubility:

610 mg/L

Temp.:

20 °C

pH:

>= 4 - <= 9

Remarks on result:

other: the solubility is independent of the pH in the range between 4 and 9

Summary of results

Water	Run	Concentration as function of equilibration time (mg/L)
		0.5 h	1 h	2 h	4 h	8 h	24 h	57 h	72 h
Unbuffered in equilibrium with CO2	1st	603.8	622.6	612.8	608.3	609.3	(559.7)	-	-
	2nd	-	-	-	-	598.3	581.0	640.3	641.2
	Mean	613.1				Standard deviation 19.3
Acidic, pH 4, phosphate buffer	1st	607.3	606.0	601.4	600.0	608.2	(555.0)	-	-
	2nd	-	-	-	-	655.4	605.6	612.4	612.7
	Mean	563.8				Standard deviation 23.3
Alkaline, pH 9, borate buffer	1st	582.6	591.3	576.6	596.2	591.7	(532.4)	-	-
	2nd	-	-	-	-	644.2	603.9	612.2	611.0
	Mean	601.1				Standard deviation 20.1

As it is evident from the concentration measurements, the solubility equilibrium is reached after 30 mins. of stirring. The 24 hrs. values from the first runs were not included in the calculation of mean and standard deviation.

Description of key information

610 mg/L at 20 °C, pH=4-9

Key value for chemical safety assessment

Water solubility:

610 mg/L

at the temperature of:

20 °C

Additional information

The water solubility of the test item was determined using flask method according to CIPAC MT 157, Part 2, similar to OECD 105.