2-[4-(4-Alkoxyphenyl)-(pyridin-2-yl)-heteromonocyclyl]phenol

Vapour pressure

Link to relevant study record(s)

Reference

Endpoint:

vapour pressure

Type of information:

experimental study

Adequacy of study:

key study

Study period:

Study initiation date - 17 March 2021; Experiment start date - 18 March 2021; Experiment end date - 31 March 2021; Study completion date - 21 May 2021

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 104 (Vapour Pressure Curve)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

effusion method: isothermal thermogravimetry

Specific details on test material used for the study:

Test Item: FAT 75637/B TE
Physical Appearance: Light yellow powder
Purity: 99.4 % all organic constituents; 95.0 % main constituent
Batch No: AT-0063765400
Manufactured Date: 21st April 2020
Expiry Date: May 27th, 2025

Temp.:

20 °C

Vapour pressure:

0 Pa

Remarks on result:

other: The vapour pressure was extrapolated from vapour pressure curve.

Temp.:

25 °C

Vapour pressure:

0 Pa

Remarks on result:

other: The vapour pressure was extrapolated from vapour pressure curve.

The obtained weight loss, evaporation rate and corresponding log Pt values of reference substances are presented. The graph of the log Pt vs Log Vt for the reference substances was presented. Correlation coefficients (r) for the  graph of reference substances for the determination of C and D constants was found to be 0.9996. Under each determination of weight loss for the test item evaporation rate and corresponding log Pt of test item at four different temperatures was presented in Table below;

Measured Temperature (°C)	Measured Temperature (K)	1/T	Am (Weight loss)(m2:)	Time in Hour (t)	VT	logVT	log PT
280	553.15	0.0018 1	0.082	4	0.00010	-4.00000	2.55878
290	563.15	0.00178	0.110	4	0.00014	-3.85387	2.69479
300	573.15	0.00174	0.201	5	0.00021	-3.67778	2.85869
270	543.15	0.00184	0.118	13	0.00005	-4.30103	2.27860
Calculated Vapor Pressure of FAT 75637/8 TE: at 20 °C (293.15K): 3.2004x10^-7Pa at 25 °C (298.15K): 6.7066x10^-7Pa

Surface area: 0.196 sq.cm

VT = Am/Ft (gcm^-2h^-1), where, F is surface area incm²of the pan and t time in hours for weight loss m in grams.

A vapour pressure curve was plotted using the inverse value of experimental temperature in K (1/T) on the X-axis and the log of the vapour pressure (Pt) determined at that temperature on the Y-axis. The vapour pressure of the test item at 20 and 25 °C was extrapolated from the vapour pressure curve using slope and intercept. The calculated vapour pressure of test item at 20 and 25 °C was 3.2004E-7 Pa and 6.7066 E-7 Pa, respectively.

Conclusions:

The vapour pressure of FAT 75637/B at 20 and 25 °C was extrapolated from the vapour pressure curve and was calculated to be 3.2004E-7 Pa and 6.7066E-7 Pa, respectively.

Executive summary:

The vapour pressure of FAT 75637/B was determined as per OECD test guideline 104. Effusion method (isothermal thermogravimetry) was performed for arriving at the vapour pressure of the test item at four different temperatures at ambient pressure. Based on the findings of this study, the vapour pressure of test item, FAT 75637/B at 20 °C and 25 °C was extrapolated from the vapour pressure curve and was calculated to be 3.2004E-7 Pa and 6.7066E-7 Pa, respectively.

Description of key information

The vapour pressure of FAT 75637/B was determined as per OECD test guideline 104. Effusion method (isothermal thermogravimetry) was performed for arriving at the vapour pressure of the test item at four different temperatures at ambient pressure. Based on the findings of this study, the vapour pressure of test item, FAT 75637/B at 20 and 25 °C was extrapolated from the vapour pressure curve and was calculated to be 3.2004E-7 Pa and 6.7066E-7 Pa, respectively.

Key value for chemical safety assessment

Vapour pressure:

0 Pa

at the temperature of:

25 °C