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EC number: 953-265-8
CAS number: -
Table 1. Results of micronucleus assay in mice.
An in vivo micronucleous assay in mice was performed for the test item according to OCDE 475 and GB15193.5-2003 Guidelines (GLP study). 50 mice, with half male and female, were randomly divided into five groups (3 treatment groups+negative and positive controls-CCP) and administered the test item dissolved in water by oral gavage for 2 days at 24h intervals. The bone marrow cells were collected from the sternum bone marrow and diluted with new born calf serum to obtain cell suspensions, which were analysed at the microscope to count the number of micronucleated polychromatic erythrocytes (MNPCE). There were no statistically significant differences in the PCE/RBC ratio and the micronucleus frequency between each test item-treated groups and negative control group (p<0.05), which indicated that the test item shows no genotoxic activity in bone marrow stem cells at doses of up to 10 g/kg bw d.
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