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Particle size distribution (Granulometry)

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Reference
Endpoint:
particle size distribution (granulometry)
Type of information:
experimental study
Adequacy of study:
key study
Study period:
26.04.2021-28.04.2021
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
ISO 13320 (Particle size analysis - Laser diffraction methods)
Deviations:
no
Qualifier:
according to guideline
Guideline:
other: CIPAC MT 187
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
Laser scattering/diffraction
Type of particle tested:
primary particle
Type of distribution:
volumetric distribution
Key result
Percentile:
D10
Mean:
3.407 µm
St. dev.:
4.1
Key result
Percentile:
D50
Mean:
37.64 µm
St. dev.:
4.1
Key result
Percentile:
D90
Mean:
151.8 µm
St. dev.:
4.1
Key result
Percentile:
other: d4,3,
Mean:
59.54 µm
St. dev.:
4.1

Table 1. Results of particle size distribution


































































Particle size



Test number and fraction size [µm]



1



2



3



4



5



Average



d10 [µm]



3.508



4.246



4.440



2.781



2.058



3.4066



d50 [µm]



35.26



38.06



37.55



41.65



35.67



37.64



d90 [µm]



135.4



146.6



145.7



170.9



160.5



151.8



* d4,3, [µm]



54.41



59.10



58.62



65.85



59.74



59.54



Average d43, [µm]



59.54



Standard deviation, [µm]



4.1



Relative Standard Deviation, [%]



6.88%



* Average d43, [µm] – The mass moment mean (De Brouckere Mean Diameter)

Conclusions:
The average particle size results for the test item are: D10 = 3.41 μm, D50 = 37.64 μm, D90 = 151.80
μm, D4,3 = 59.54 μm.
Executive summary:

The particle size distribution for the test substance was determined according to CIPAC MT 187/ISO 13320-1, under GLP conditions. The average particle size results for the test item are: D10 = 3.41 μm, D50 = 37.64 μm, D90 = 151.80 μm, D4,3 = 59.54 μm (Mass moment mean - De Brouckere Mean Diameter).

Description of key information

Key study. Method according to CIPAC MT 187/ISO 13320-1, GLP study. The average particle size results for the test item are: D10 = 3.41 μm, D50 = 37.64 μm, D90 = 151.80μm, D4,3 = 59.54 μm.

Additional information