Registration Dossier
Registration Dossier
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EC number: - | CAS number: -
Endpoint summary
Administrative data
Description of key information
OECD 201 (toxicity to aquatic algae), Augusiak (2020), 72 h NOEC: 2.2 mg/L; 72 h ErC10: 3.9 mg/L; 72 h ErC50: 23 mg/L
OECD 202 (short-term toxicity to Daphnia magna), Augusiak (2020), 48 h EC50 45 mg/L
OECD 203 (short-term toxicity to fish), Augusiak (2020), 96 h LC50: > 70 mg/L
OECD 209 (toxicity to micro-organisms), Timmer (2020), 3 h EC50: 367 mg/L; 3 h EC10: 134 mg/L
Additional information
The strategy for aquatic toxicity testing focused on the constituent 2,2'-phenyliminodiethanol (EC# 204-368-5). The registered UVCB chemical substance is composed of the following main constituents:
1. N-Phenyl-diethanolamine, oligomers with formaldehyde (35 - 65 % w/w)
2. 2,2'-phenyliminodiethanol (30 - 60 % w/w)
However, due to the aqueous instability of N-Phenyl-diethanolamine, oligomers with formaldehyde constituent, it is rapidly transformed abiotically to 2,2'-phenyliminodiethanol, with a half-life of 0.15 hours (25 °C) and 0.66 hours (15 °C). The kinetics are based on the OECD 111 study and the transformation products were identified as part of analytical method development and validation (see Section 8 of the technical dossier). Such rapid transformation, that is independent of biological interaction, means that environmental exposure of N-Phenyl-diethanolamine, oligomers with formaldehyde to aquatic organisms will not occur in accordance with the identified uses. This constituent will be transformed to 2,2'-phenyliminodiethanol before any emissions reach the aquatic environment.
Therefore, during aquatic toxicity testing, all test solutions were prepared in representative media and stirred for a 3 hour period. Each study commenced after analytical verification of the absence of the N-Phenyl-diethanolamine, oligomers with formaldehyde constituent, and equivalent increase in concentration of 2,2'-phenyliminodiethanol.
This approach is consistent with OECD Guidance Document 23 on Aquatic Toxicity Testing of Difficult Substances and Mixtures (2019).
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