Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Endpoint summary

Administrative data

Description of key information

OECD 201 (toxicity to aquatic algae), Augusiak (2020), 72 h NOEC: 2.2 mg/L; 72 h ErC10: 3.9 mg/L; 72 h ErC50: 23 mg/L

OECD 202 (short-term toxicity to Daphnia magna), Augusiak (2020), 48 h EC50 45 mg/L

OECD 203 (short-term toxicity to fish), Augusiak (2020), 96 h LC50: > 70 mg/L

OECD 209 (toxicity to micro-organisms), Timmer (2020), 3 h EC50: 367 mg/L; 3 h EC10: 134 mg/L

Additional information

The strategy for aquatic toxicity testing focused on the constituent 2,2'-phenyliminodiethanol (EC# 204-368-5).  The registered UVCB chemical substance is composed of the following main constituents:

1. N-Phenyl-diethanolamine, oligomers with formaldehyde (35 - 65 % w/w)

2. 2,2'-phenyliminodiethanol (30 - 60 % w/w)

However, due to the aqueous instability of N-Phenyl-diethanolamine, oligomers with formaldehyde constituent, it is rapidly transformed abiotically to 2,2'-phenyliminodiethanol, with a half-life of 0.15 hours (25 °C) and 0.66 hours (15 °C).  The kinetics are based on the OECD 111 study and the transformation products were identified as part of analytical method development and validation (see Section 8 of the technical dossier).  Such rapid transformation, that is independent of biological interaction, means that environmental exposure of N-Phenyl-diethanolamine, oligomers with formaldehyde to aquatic organisms will not occur in accordance with the identified uses.  This constituent will be transformed to 2,2'-phenyliminodiethanol before any emissions reach the aquatic environment.

Therefore, during aquatic toxicity testing, all test solutions were prepared in representative media and stirred for a 3 hour period.  Each study commenced after analytical verification of the absence of the N-Phenyl-diethanolamine, oligomers with formaldehyde constituent, and equivalent increase in concentration of 2,2'-phenyliminodiethanol.

This approach is consistent with OECD Guidance Document 23 on Aquatic Toxicity Testing of Difficult Substances and Mixtures (2019).