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EC number: -
CAS number: -
In-vitro gene mutation in bacteria: Key study. Method according to OECD 471, GLP study. The test item does not have mutagenic activity under the test conditions, with or without metabolic activation.
The mutagenic activity of the test item was determined according to OECD 471 under GLP conditions. Four different histidine dependent Salmonella typhimurium strains (TA1535, 1537, 98 & 100) and a tryptophan dependent Escherichia coli WP2 uvrA strain were exposed to the test subtance in EtOH solution ranging from 50 to 5000 μg/plate in triplicate, including negative, positive and positive-solvent controls with and without metabolic activation. The plates were screened for revertant colonies that gained the ability to be independent of the former dependent histidine or tryptophane. No increase in revertant colonies could be observed. The test item does not have mutagenic activity under the test conditions, with or without metabolic activation.
In-vitro gene mutation in bacteria:
Based on the available information, the substance is not classified for mutagenicity according to CLP Regulation (EC) no. 1272/2008.
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