Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 201-360-3 | CAS number: 81-55-0
Endpoint summary
Administrative data
Description of key information
Not skin irritant.
Not eye irritant.
Key value for chemical safety assessment
Additional information
No experimental data on the skin and eye irritation potential of target substance was found in literature, for this reason, data on similar substances was considered together with the estimation of the OECD QSAR.
No inclusion rules are met for the eye irritation while for skin irritation an alert was found due to the presence of a “phenols and ketones” type structure. The substance can not be however identified by this two chemical categories as the ketone in the anthraquinone is part of a system of fused rings with a high resonance and a different reactivity respect to the ketones. Same consideration for the “phenols” alert: for skin irritation this specific alert is not relevant to phenols fused to aromatic rings and for this reason, it is considered not applicable to the target substance.
Results from studies carried out on 1,4-dihydroxyanthraquinone were negative as the substance was found to be not eye nor skin irritant. On the other hand, 1,4,5,8-tetraaminoanthraquinone has a harmonized classification as skin irritant cat. 2 (H315) and eye dam. 1 (H318). The target substance could behave likewise an amino derivative in case of a systemic exposure where the endogenous enzymes could reduce the nitro group to an amino one. However, this reaction is not expected to occur in the skin and the eyes therefore, the classification of the tetra-amino derivative is not fully representative of the behaviour of the target substance.
Further information are available in the attachment in IUCLID section 13.2.
Justification for classification or non-classification
Based on analysis of structural alerts by QSAR tools and available data on structural analogues, the substance is not classified for skin and eye irritation according to the CLP Regulation (EC 1272/2008).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
