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Environmental fate & pathways

Hydrolysis

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Administrative data

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Reference
Endpoint:
hydrolysis
Type of information:
experimental study
Adequacy of study:
key study
Study period:
JUN 2020
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Reason / purpose for cross-reference:
reference to same study
Principles of method if other than guideline:
Standard production material is hydrolyzed with water, then titrated with 0.5 N HCl to determine the base concentration of the solution. Exhibit the complete hydrolysis of the material within a set period of time.
GLP compliance:
no
Remarks:
Test was done in-house because chemical behaviour of the substance is commonly known. Test was done to support the RA-approach, that the hydrolysis products have to be assessed in ecotoxicology testing instead of the parent substance.
Radiolabelling:
no
Analytical monitoring:
no
Transformation products:
yes
No.:
#1
No.:
#2
% Recovery:
0
pH:
8.48
Duration:
144 s
Remarks on result:
other: see 'Remarks'
Remarks:
As the substance undergoes fast hydrolysis (within < 5 minutes) the half-life time of the hydroylsis was not determined

The time needed to complete the titration is 3 minutes and 16 seconds. There are two endpoints:

1. NaOH titration (NaM hydrolysis) 2 minutes, 24 seconds. pH = 8.48

2. Sodium Carbonate titration (by-product of air exposure). 3 minutes, 16 seconds. pH = 6.02

The starting pH of the alkoxide solution is 12.5 as a 1:1 dilution in deionized water.

Validity criteria fulfilled:
yes
Conclusions:
The test substance undergoes very fast hydrolysis within 144 seconds.
Executive summary:

The hydrolytical behaviour of the test substance was assessed in-house via titration method by company:

Standard production material is hydrolyzed with water, then titrated with 0.5 N HCl to determine the base concentration of the solution. Exhibit the complete hydrolysis of the material within a set period of time. The time needed to complete the titration is 3 minutes and 16 seconds. There are two endpoints:

1. NaOH titration (NaM hydrolysis) 2 minutes, 24 seconds. pH = 8.48

2. Sodium Carbonate titration (by-product of air exposure). 3 minutes, 16 seconds. pH = 6.02

The starting pH of the alkoxide solution is 12.5 as a 1:1 dilution in deionized water.

Description of key information

The hydrolytical behaviour of the test substance was assessed in-house via titration method by company:

Standard production material is hydrolyzed with water, then titrated with 0.5 N HCl to determine the base concentration of the solution. Exhibit the complete hydrolysis of the material within a set period of time. The time needed to complete the titration is 3 minutes and 16 seconds. There are two endpoints:

1. NaOH titration (NaM hydrolysis) 2 minutes, 24 seconds. pH = 8.48

2. Sodium Carbonate titration (by-product of air exposure). 3 minutes, 16 seconds. pH = 6.02

The starting pH of the alkoxide solution is 12.5 as a 1:1 dilution in deionized water.

Key value for chemical safety assessment

Additional information

In-house testing took place at ambient conditions, which was assumed to be 25 °C and 1013 hPa. Nevertheless the exact value for the temperature does not affect the hydrolysis rate significantly because hydrolysis occurs in any case within seconds. As the substance undergoes fast hydrolysis (within < 5 minutes) the half-life time of the hydroylsis was not determined.