Registration Dossier
Registration Dossier
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EC number: 232-623-0 | CAS number: 9001-66-5
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- GLP compliance:
- no
- Type of method:
- flask method
- Specific details on test material used for the study:
- Lot PF 907
- Key result
- Water solubility:
- > 102 g/L
- Conc. based on:
- test mat.
- Temp.:
- 30 °C
- pH:
- ca. 7
- Remarks on result:
- other: The pH was not reported and was assumed to be 7
- Details on results:
- The highest concentration of monoamine oxidase in water is achieved at 102 mg/mL. At this concentration, the solution is in a gel-like state. Adding additional lyophilized powder into this solution will make mixing impossible.
- Conclusions:
- Monoamine is extremely soluble in water. It was not possible to measure the full extent of monoamine oxidase solubility as the solution becomes too viscous above 102 mg/mL and it cannot be mixed sufficiently to confirm all of the lyophilized powder was dissolved. Therefore, the water solubility of monoamine oxidase is reported as > 102 g/L.
Reference
The final concentration of CDX-616 is calculated based on the amount of lyophilized powder added and the final volume of the solution (Table 1). The UV280nm absorbance of each solution is measured to confirm that the OD is within linear range.
Table 1. Final volume and concentration of CDX-616 in water
Weight of CDX-616 (mg) |
Water (mL) |
Total Volume (mL) |
45.0 |
5.00 |
5.10 |
120.0 |
5.00 |
5.15 |
226.5 |
5.00 |
5.25 |
322.0 |
5.00 |
5.27 |
551.0 |
5.00 |
5.40 |
1001.3 |
5.00 |
5.90 |
Description of key information
Monoamine is extremely soluble in water. It was not possible to measure the full extent of monoamine oxidase as the solution becomes too viscous above 102 mg/mL and it cannot be mixed sufficiently to confirm all of the lyophilized powder was dissolved. Therefore, the water solubility of monoamine oxidase is reported as > 102 g/L.
Key value for chemical safety assessment
- Water solubility:
- 102 g/L
- at the temperature of:
- 30 °C
Additional information
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