Registration Dossier
Registration Dossier
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EC number: 953-082-3 | CAS number: -
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro cytogenicity / micronucleus study
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- RIFM fragrance ingredient safety assessment, Valencene, CAS Registry Number 4630-07-3
- Author:
- Api, A.M., Belsito, D., Botelho, D., Bruze, M., Burton Jr, G.A., Buschmann, J., Dagli, M.L., Date, M., Dekant, W., Deodhar, C. and Francis, M.
- Year:
- 2 018
- Bibliographic source:
- Food and Chemical Toxicology, 118, pp.S141-S146
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 487 (In vitro Mammalian Cell Micronucleus Test)
- GLP compliance:
- yes
- Type of assay:
- in vitro mammalian cell micronucleus test
Test material
- Reference substance name:
- [1R-(1α,7β,8α)]-1,2,3,5,6,7,8,8a-octahydro-1,8a-dimethyl-7-(1-methylvinyl)naphthalene
- EC Number:
- 225-047-6
- EC Name:
- [1R-(1α,7β,8α)]-1,2,3,5,6,7,8,8a-octahydro-1,8a-dimethyl-7-(1-methylvinyl)naphthalene
- Cas Number:
- 4630-07-3
- Molecular formula:
- C15H24
- IUPAC Name:
- 3-isopropenyl-4a,5-dimethyl-1,2,3,4,4a,5,6,7-octahydronaphthalene
1
- Specific details on test material used for the study:
- Reported as: Valencene
Method
Species / strain
- Species / strain / cell type:
- lymphocytes: Human peripheral blood lymphocytes
- Metabolic activation:
- with and without
- Metabolic activation system:
- S9
- Test concentrations with justification for top dose:
- 2000 µg/mL in the presence and absence of metabolic activation for 3 and 24 hours.
- Vehicle / solvent:
- dimethyl formamide (DMF)
Results and discussion
Test results
- Species / strain:
- lymphocytes: Human peripheral blood lymphocytes
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
Applicant's summary and conclusion
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