Registration Dossier
Registration Dossier
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EC number: 907-481-4 | CAS number: -
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 976
- Report date:
- 1976
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Reaction mass of 1,1-bis(phenethyloxy)ethane and [2-(1-ethoxyethoxy)ethyl]benzene
- EC Number:
- 907-481-4
- Molecular formula:
- C18H22O2 + C12H18O2
- IUPAC Name:
- Reaction mass of 1,1-bis(phenethyloxy)ethane and [2-(1-ethoxyethoxy)ethyl]benzene
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- - Description: Clear liquid
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 200 to 300 g
- Fasting period before study: Approx. 18 hours prior to the administration of the test material
- Diet: ad libitum
- Water: ad libitum
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- 5000 mg/kg bw
- No. of animals per sex per dose:
- 10
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Examinations performed: mortality, toxicity, pharmacological effects, gross pathology (rats who died were examined for visually observable abnormalities of external structures and viscera)
Results and discussion
Effect levels
- Key result
- Sex:
- male
- Dose descriptor:
- discriminating dose
- Effect level:
- 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- One animal died on day 13
- Clinical signs:
- other: None
- Gross pathology:
- Mottled liver, dark lungs, small intestines, and a red stomach was observed in the animal which died
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
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