Registration Dossier
Registration Dossier
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EC number: 457-900-5 | CAS number: -
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 15 May - 14 Jun 2007
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP - Guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 007
- Report date:
- 2007
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Food and Consumer Product Safety Authority, Den Haag, The Netherlands
- Type of method:
- other: estimation method
- Partition coefficient type:
- octanol-water
Test material
Reference
- Name:
- Unnamed
- Type:
- Constituent
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- - Name of test material (as cited in study report): PM-5927
- Physical state:off-white powder
- Lot/batch No.:07-02
- Expiration date of the lot/batch:05.02.2008
- Storage condition of test material: at room temperature protected from light
Study design
- Analytical method:
- high-performance liquid chromatography
Results and discussion
Partition coefficientopen allclose all
- Type:
- Pow
- Partition coefficient:
- 34
- Temp.:
- 20 °C
- Type:
- log Pow
- Partition coefficient:
- 1.53
- Temp.:
- 20 °C
Any other information on results incl. tables
Results
No test substance was detected in the pretreated samples from the blank octanol mixture. No tendency to increased values was obtained. However, the spread on the analysed concentrations was relatively high i.e. a maximum difference (MD) of > 15%. To investigate the reason for it, it was decided to perform a second main study.
Study # |
Stirring time [hours] |
Individual [g/L] |
Analysed concentration |
||
Mean 1 [g/L] |
Mean 2 [g/L] |
MD [%] |
|||
1 |
24 |
17.7 |
17.7 |
18.1 |
25.8 |
1 |
24 |
17.8 |
|||
1 |
48 |
15.8 |
15.9 |
||
1 |
48 |
15.9 |
|||
1 |
72 |
20.4 |
20.6 |
||
1 |
72 |
20.8 |
|||
2 |
24 |
16.7 |
16.9 |
18.0 |
27.9 |
2 |
24 |
17.1 |
|||
2 |
48 |
16.0 |
16.0 |
||
2 |
48 |
16.0 |
|||
2 |
72 |
21.1 |
21.2 |
||
2 |
72 |
21.2 |
|||
In the second main study, similar results as during main study 1 were obtained. No possible reason for the relatively high spreads on the analysed concentrations could be given. The results were therefore accepted and the n-octanol solubility was calculated using the results of main study 1 and 2. The mean n-octanol solubility is 18.0 g/L.
Water solubility
The water solubility was 0.530 g/L.
The Pow, calculated as the quotient of the octanol- and water solubility, is 34.0. It corresponds with a log Pow value of 1.53.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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