Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: -
CAS number: -
Table: Mean achieved actual and nominal aerosol concentrations
Mean Achieved Concentration(mg/L)
Standard Deviation of Achieved Concentration (mg/L)
Table: Mean achieved particle size distribution data (MMAD and GSD)
Mean Mass Median Aerodynamic Diameter (MMAD) (mm)
Geometric Standard Deviation(GSD)†
Respirable Fraction(% < 4mm)
The OECD guideline gives the normal GSD range as 1.5-3.0. This range was
exceeded in this study, however the relatively high values as low as
were practically achievable.
The particle size distribution data are presented graphically in
Figure 3 and detailed in Appendix 2, both as Automatic and Manual
Note that automatic calculations are made from the system
software, these are considered to be accurate when the particle size
distribution approximates to a ‘normal’ distribution. In this study, the
size distribution did not appear to approximate to ‘normal’; hence a
manual calculation was made as a Log-Log plot, to estimate the 50% point
for cumulative mass.
on theacute inhalationtoxicity
ofpNMC oxide (6:2:2)
in male and female Crl:WI Wistar rats was generated ina
OECD N° 403, EU Method B.2 and EOP OPPTS 870.1300.
Based on the results of a
Sighting Exposure with two animals of both sexes, the main study with
five male and five female rats was performed at the target concentration
of 0.5 mg/L. Animals were exposed to the test atmosphere for 4 hours
using a nose-only exposure system. Aerosol concentration was measured
gravimetrically 17 times in the Sighting Exposure and in the main study
during each 4-hour exposure and the particle size distribution of the
test aerosol was determined 3 times. The day of exposure was designated
as Day 0 followed by a 14-day observation period. Clinical observations
were performed on all animals during exposure at hourly intervals,
following removal from restraint, approximately 1 hour after exposure,
and daily for 14 days thereafter. Body weight was measured on Days 0
(before the exposure), 1, 3, 7 and 14. Gross necropsy was performed on
all animals on Day 14.
No mortality occurred during the study. Laboured respiration (slight),
noisy respiration (slight), fur staining by test item (on the head and
nose) and wet fur (on the whole body) were observed from Day 0 up to Day
8. All animals were symptom-free from Day 9. Slight (male, female) to
moderate (male only) body weight losses were recorded on Days 0-3. The
body weight gains were normal between Days 3-14. Necropsy revealed test
item related grey diffuse/focal discolouration of all lobes of lungs in
one out of five male and four out of five females of the main study.
Under the experimental conditions of this study, no mortality occurred
in the main study when exposed to a test atmosphere concentration of
0.50 mg/L as a maximum achievable concentration for 4 hours. The acute
inhalation median lethal concentration (LC50) of pNMC oxide (6:2:2) in
male and female Crl:WI rats was therefore considered to be above 0.50
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again