3-[(phenylcarbamoyl)amino]phenyl 4-methylbenzenesulfonate

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

16 May 2018 - 17 May 2018

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Version / remarks:

27 July 1995

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

column elution method

Specific details on test material used for the study:

- Storage conditions: The test material was stored in a dark storage place at room temperature.
- Test material identification and stability under storage: The infrared (IR) spectrum of the test material measured at the test facility was confirmed to be identical to that provided by the sponsor. In addition, the IR spectrum of the test material after the completion of the experiment was the same as that before the start of the experiment, and it indicated that the test material was stable under storage conditions.

Key result

Water solubility:

0.027 mg/L

Conc. based on:

test mat.

Temp.:

20 °C

pH:

>= 5.7 - <= 5.9

Details on results:

It was judged that the test results were valid because maximum difference of the concentration was less than 30 %.

Confirmation of equilibrium state

The concentration of test material in the eluting fraction was measured after the test water was flowed at 0.4 mL/min through the column for measurement of water solubility. It was judged from the following results that the concentration had reached equilibrium after 19.0 hours:

Sampling time       n       Concentration (mg/L)       Relative SD (%)

3.0                          1       0.0243                            

4.0                          1       0.0241                            14.5

19.0                        1       0.0309              

Results of water solubility determination

Flow rate	pH	Water solubility (mg/L)			Standard deviation	Maximum difference (%)
		Measurement value	Average	Average of all values
0.4 mL/min	5.8 5.9 5.9 5.9 5.7	0.0275 0.0292 0.0279 0.0267 0.0287	0.0280	0.0269	0.000984	14.9
0.2 mL/min	5.9 5.9 5.9 5.7 5.8	0.0248 0.0249 0.0258 0.0268 0.0266	0.0258		0.000912

Conclusions:

Under the conditions of this study the water solubility of the test material is 0.0269 mg/L at 20 °C.

Executive summary:

The water solubility of the test material was determined in accordance with the standardised guideline OECD 105 and under GLP conditions, following the column elution method.

The analysis was carried out by HPLC, with 5 repetitions at each flow rate (0.4 mL/min and 0.2 mL/min).

Under the conditions of this study the water solubility of the test material is 0.0269 mg/L at 20 °C.

Description of key information

The water solubility of the test material is 0.0269 mg/L at 20 °C.

Key value for chemical safety assessment

Water solubility:

0.027 mg/L

at the temperature of:

20 °C

Additional information

The water solubility of the test material was determined in accordance with the standardised guideline OECD 105 and under GLP conditions, following the column elution method. The study was awarded a reliability score of 1 in accordance with the criteria set forth by Klimisch et al. (1997).

The analysis was carried out by HPLC, with 5 repetitions at each flow rate (0.4 mL/min and 0.2 mL/min).

Under the conditions of this study the water solubility of the test material is 0.0269 mg/L at 20 °C.