Registration Dossier
Registration Dossier
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EC number: 203-613-3 | CAS number: 108-75-8
Endpoint summary
Administrative data
Description of key information
The test item was found to be not readily biodegradable.
Additional information
OECD 301F
The purpose of this study was to determine the ready biodegradability of the test item 2,4,6-Collidine. The test item was exposed to aerobic activated sludge from the aeration tank of a domestic waste water treatment plant for 28 days. The biodegradation was followed by the oxygen uptake of the microorganisms during exposure. As a reference item sodium benzoate was tested simultaneously under the same conditions as the test item, and functioned as a procedure control. Aerobic activated sludge from a domestic waste water treatment plant was used in this study. A manometric Test System with a BSB/BOD-Sensor-System and flasks containing a volume of approximately 500 mL were used. The test flasks were incubated at 22°C ± 1°C. The pressure decrease in the reaction vessels was measured over complete experimental phase of 28 days using the BSB/BODSensor-System. The test flasks were closed gas-tight by a measuring head. Potassium hydroxide solution (45%) was used for trapping the produced carbon dioxide. The amount of O2 consumed by the activated sludge was calculated from the decrease of pressure in the reaction vessel. Nitrogen is part of the molecular structure of the test item; therefore nitrification (ThODNO3) was considered for the evaluation of the results. The criterion for ready biodegradability under the conditions of a manometric respirometry test is the degradation of the test item of at least 60%, reached within a 10-day window; the 10-day window starts when the degradation of the test item reaches at least 10% degradation. The test item never reached 10% biodegradation. The mean biodegradation percentage at the end of the 28-day exposure period was 3% (ThODNO3). If no nitrification is considered, the mean biodegradation was 3% (ThODNH4) after 28 days of incubation. The criterion of the 10 day window was not fulfilled. Therefore, 2,4,6-Collidine is considered to be not readily biodegradable. The reference item sodium benzoate was sufficiently degraded to 77% after 14 days and to 79% after 28 days of incubation.
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