Registration Dossier
Registration Dossier
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EC number: 201-579-4 | CAS number: 85-00-7
Solubility in organic solvents / fat solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- solubility in organic solvents / fat solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- other: OECD TG 105
- Principles of method if other than guideline:
- Batch: ASY169
Purity: 100 % w/w
Storage conditions: 5 °C - GLP compliance:
- yes
- Key result
- Medium:
- methanol
- Solubility:
- 25 g/L
- Temp.:
- 20 °C
- Medium:
- acetone
- Solubility:
- < 0.1 g/L
- Temp.:
- 20 °C
- Medium:
- other: dichloromethane
- Solubility:
- < 0.1 g/L
- Temp.:
- 20 °C
- Medium:
- toluene
- Solubility:
- < 0.1 g/L
- Temp.:
- 20 °C
- Medium:
- ethyl acetate
- Solubility:
- < 0.1 g/L
- Temp.:
- 20 °C
- Medium:
- other: hexane
- Solubility:
- < 0.1 g/L
- Temp.:
- 20 °C
- Test substance stable:
- yes
- Details on results:
- The solvent solubility of the test substance in methanol at approximately 20 °C is 25 g /(L solution). The solvent solubility in acetone, dichloromethane, toluene, ethyl acetate and hexane at approximately 20 °C is < 0.1 g /(L solution).
- Conclusions:
- Solvent solubility of the substance at about 20 °C was 25 g/L for methanol and <0.1 g/L in acetone, dichloromethane, toluene, ethyl acetate and hexane
- Executive summary:
The solubility of test substance has been determined in six organic solvents following the OECD 105 flask method in compliance with GLP. The solvent solubility of the test substance in methanol at about 20 °C was 25 g /(L solution), whereas in acetone, dichloromethane, toluene, ethyl acetate and hexane the solubility was under 0.1 g /(L solution).
Reference
INSTRUMENTAL ANALYSIS
In all cases the resultant concentration of divalent test substance ions was found to be < 0.004 mg/mL solution. Since divalent test substance ions account for 50.9 % of the total, this is equivalent to < 0.008 mg per mL of solution test substance, i.e. < 0.1 g /L.
Table 1 Gravimetric Analyis
| 24 hours | 48 hours |
Final Weight of vial (g) | 53.4726 | 50.5104 |
Tare Weight of vial (g) | 53.2132 | 50.2655 |
Weight of test substance in 10cm3 saturated solution (g) | 0.2594 | 0.2449 |
Solubility (g/L) | 25.94 | 24.49 |
Mean solubility (2 sig figs) (g/L) | 25 |
|
Description of key information
The test substance is soluble at 25 g/L in methanol and <0.1 g/L in acetone, dichloromethane, toluene, ethyl acetate and hexane, OECD TG 105, Husband, 2001
Key value for chemical safety assessment
- Solubility in organic solvents at 20°C:
- 25 g/L
Additional information
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