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EC number: 951-084-9
CAS number: 1822310-42-8
GLP compliant OECD 423: LD50 (oral) > 2000 mg/kg bw
objective of the present study was to identify potential toxic effects
of the test item after single oral administration to rats in a stepwise
Following a sighting test at dose levels of 300 mg/kg
b.w. and 2000 mg/kg b.w. in one female rat per dose group, a further
group of four fasted females was given a single oral dose of the test
material, as a formulation in corn oil, at a dose level of 2000 mg/kg
body weight. Clinical signs and body weight development were monitored
in all animals during the study. All animals were subjected to gross
Mortality: There were no deaths.
Clinical Observations: Transient piloerection was noted 4
hours after dosing in the animal treated at a dose level of 300 mg/kg.
There were no signs of systemic toxicity noted in the remaining animals.
Body Weight: All animals showed expected gains in body
Necropsy: The uterus of the animal treated with 300 mg/kg
was filled with liquid, indicative of unspecific changes during the
physiological oestrous cycle. There were no signs of abnormalities noted
at necropsy in the remaining animals.
the conditions of the present study, it is concluded that the test item
has no acute toxic potential and that the LD50 value is higher than 2000
mg/kg bw after single oral administration in female rats.
Based on the provided information the test item is not classified for
acute oral toxicity according to the EU Regulation (EC) No 1272/2008 on
Classification, Labelling and Packaging of Substances and Mixtures.
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