Registration Dossier

Diss Factsheets

Physical & Chemical properties

Partition coefficient

Currently viewing:

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study with acceptable restrictions
Qualifier:
according to guideline
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
GLP compliance:
no
Type of method:
HPLC method
Partition coefficient type:
octanol-water
Specific details on test material used for the study:
SOURCE OF TEST MATERIAL
- Source and lot/batch number of test material:test item supplied by sponsor/91112Y
- Expiration date of the lot/batch:12 March 2021

STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material:Ambient temperature (10~30oC)
- Stability under storage conditions:Stability (water, light, etc.)

TREATMENT OF TEST MATERIAL PRIOR TO TESTING
- Treatment of test material prior to testing:Test item stock solution was dissolved in dichloromethane


Analytical method:
high-performance liquid chromatography
Key result
Type:
log Pow
Partition coefficient:
>= 5.7 - <= 8.6
Temp.:
35 °C
Remarks on result:
other: pH is not available
Type:
log Pow
Partition coefficient:
8.1
Temp.:
35 °C
Remarks on result:
other: the weighted average logPow of main constitut
Details on results:
The test iem in HPLC spectrogram shows four peaks. The first two peaks are impurities, the last two are main constituents. The substance is a multi-constituent substance with two components, anf these two components are homologues, according to OECD117 guideline, the weight average logPow of main constituent is 8.1.
Conclusions:
LogPow values were calculated in the range of 5.7~8.6.
Executive summary:

The partition coefficient of the test item has been determined as log P = 5.7~8.6 at 35°C according to OECD Guideline 117 (HPLC Method).

Description of key information

The partition coefficient of the test item has been determined in the range of 5.7 -8.6 at 35°C according to OECD Guideline 117 (HPLC Method).

Key value for chemical safety assessment

Log Kow (Log Pow):
8.1
at the temperature of:
35 °C

Additional information