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EC number: 433-730-7 | CAS number: 23926-51-4 L-THREONINETHYLESTER
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics
- Adequacy of study:
- weight of evidence
Data source
Materials and methods
- Objective of study:
- other: Assessment of toxicokinetic behaviour
Test material
Constituent 1
Results and discussion
Applicant's summary and conclusion
- Conclusions:
- No studies are available. Based on the molecular structure, molecular weight, water solubility, and octanol-water partition coefficient of L-TEE, it can be expected that the oral and inhalational absorption rates maybe high and the dermal absorption rate is considered moderate. No data on distribution is available, but based on the effects seen in the 28-day study and physical/chemical data, L-TEE is expected to be distributed though the body.
L-TEE is an ester formed by L-threonine and ethanol, both of which are substances that are readily metabolized in the body. A high degree of endogenous hydrolysation into these substances is expected due to the activity of normally occurring esterases. However, no specific data on the hydrolysation rates are available
Based on the anticipated metabolic fate and the resulting formation of L-threonine and ethanol, it is considered relevant to consider data on these substances when evaluating L-TEE. Hence, no bioaccumulation is expected. - Executive summary:
In a 28 days oral toxicological study rats were exposed to L-TEE at 250, 500 or 1000 mg/kg bw/day.No adverse findings were observed, however, minimal/slight cortico-medullary mineralisation in the kidneys and increased lymphocyte counts were observed in females treated at all dose levels. From this, it can be deduced that L-TEE is absorbed from the gastro-intestinal tract. Due to lack of specific data on absorption rates, an oral absorption rat of 100% is therefore anticipated.
As no adequate data on inhalation is available, an absorption of 100% is anticipated.
L-TEE is a small molecule with a very high water solubilty so some dermal absorption may be expected. Having some liphophilic properties ethanol is considered to have a higher potential for dermal absorption as L-TEE and as an worst case assumption the same absorption rate for ethanol may be used for L-TEE. For dermal absorption of ehtanol, an absorption rate of 10 % has been found (Pendlington et al. 2001, Food and Chemical Toxicology 39 (2001) 169–174), thus the same abosrption rate is applied for L-TEE.
Based on the molecular structure, molecular weight, water solubility, and octanol-water partition coefficient of L-TEE it can be expected that the oral and inhalational absorption rates maybe high and the dermal absorption rate is considered moderate. No data on distribution is available, but based on the effects seen in the 28-day study and physical/chemical data, L-TEE is expected to be distrubuted thought the body. L-TEE is an ester formed by L-threonine and ethanol, both of which are substances that are readily metabolized in the body. A high degree of endogenous hydrolysation into these substances is expected due to the activity of normally occurring esterases. However, no specific data on the hydrolysation rates are available. Based on the antipicated metabolic fate and the resulting formation of L-threonine and ethanol, it is considered relevant to consider data on these substances when evaluating L-TEE. Hence, no bioaccumulation is expected.
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