Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 433-730-7 | CAS number: 23926-51-4 L-THREONINETHYLESTER
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2000.04.04-2000.09.21
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study performed in accordance with GLP.
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- Principles of method if other than guideline:
- NA
- GLP compliance:
- yes
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Type:
- log Pow
- Partition coefficient:
- < 0.3
- Temp.:
- 20 °C
- Remarks on result:
- other: NA
- Details on results:
- The retention time of L-TEE : 2.484 min.
The retention time of Formamide (the void volume marker): 2.437 min.
The retention time of Butanone (the calibration compound): 3.405 min. - Conclusions:
- The partition coefficient of L-TEE was determined in accordance with EU Method A.8 and OECD Guideline 117. The log Pow of L-TEE was determined to be below 0.3
- Executive summary:
The partition coefficient of L-TEE was determined in accordance with EU Method A.8 and OECD Guideline 117.
The octanol-water partition coefficient of L-TEE was evaluated using the HPLC simulation technique with methanol-water, 55:45 as eluent. L-TEE eluted as a single component with a retention time effectively equivalent to that of the void volume marker formamide, and therefore the partition coefficient, whilst being below a log Pow value of 0.3, could not be more fully numerically evaluated.
Reference
NA
Description of key information
The log Pow of L-TEE was determined to be below 0.3
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 0.3
- at the temperature of:
- 35 °C
Additional information
The partition coefficient of L-TEE was determined in accordance with EU Method A.8 and OECD Guideline 117.
The octanol-water partition coefficient of L-TEE was evaluated using the HPLC simulation technique with methanol-water, 55:45 as eluent. L-TEE eluted as a single component with a retention time effectively equivalent to that of the void volume marker formamide. Therefore, the partition coefficient could not be more numerically evaluated, but is below 0.3.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
