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EC number: 433-730-7 | CAS number: 23926-51-4 L-THREONINETHYLESTER
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Particle size distribution (Granulometry)
Administrative data
Link to relevant study record(s)
- Endpoint:
- particle size distribution (granulometry)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2007.08.31 to 2007.11.29
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study performed in accordance with recognised test guidance - European Commision Guidance Document on the Determination of Particle Size Distribution, Fibre Length and Diameter Distribution of Chemical Substances. EUR 20268 EN [draft].
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- according to guideline
- Guideline:
- other:
- Deviations:
- not applicable
- Principles of method if other than guideline:
- The particle size is measured by laser diffraction in combination with Mie theory as described in European Commision Guidance Document on the Determination of Particle Size Distribution, Fibre Lenght and Diameter Distribution of Chemical Substances. EUR 20268 EN [draft].
- GLP compliance:
- yes
- Type of method:
- Laser scattering/diffraction
- Type of distribution:
- volumetric distribution
- Mass median aerodynamic diameter:
- > 562 - < 810 µm
- Geometric standard deviation:
- > 46.4 - < 102.9
- Percentile:
- D10
- Mean:
- >= 81.178 - <= 97.926 µm
- St. dev.:
- 0
- Percentile:
- D50
- Mean:
- >= 507.8 - <= 731.2 µm
- St. dev.:
- 0
- Percentile:
- D90
- Mean:
- >= 1 292 - <= 1 444 µm
- St. dev.:
- 0
- Conclusions:
- A bimodal distribution of size was observed, which was considered to be broadly representative of the “short” and “long” cross-sections of a distinctly cylindrical (“fibrous”) particulate or crystalline nature, and which corresponded to the visual observations. Three data sets were evaluated, and these showed some variability in the findings, therefore overall mean values were not generated. The d(0.5) values (the particle size representing the mid-point in each averaged distribution set) were between 507.8 and 731.2 μm. The d(0.1) and d(0.9) values (the particle sizes representing the 10% and 90% points in the distributions) were respectively between 81.2 and 97.9 μm and 1292 and 1444 μm.
Because of the asymmetric nature of the test substance particles, and the inherent variability of the measurements, overall mean values for the mass median aerodynamic diameter (MMAD) and geometric standard deviation (GSD) values were not able to be calculated. Values for the three data sets were respectively between 562 and 810 μm (MMAD), and 46.4 and 102.9 μm (GSD). The data distribution tables (considering all data sets) indicate that the mean proportion of test substance found below 10 μm (actual value 10.00 μm) was nil, that below nominally 50 μm (actual value 52.5 μm) was less than 1%, and that below nominally 100 μm (actual value 104.7 μm) was between 11 and 19%. - Executive summary:
The particle size of L-TEE was determined by laser diffraction in combination with Mie theory1. A bimodal distribution of size was observed, which was considered to be broadly representative of the “short” and “long” cross-sections of a distinctly cylindrical (“fibrous”) particulate or crystalline nature, and which corresponded to the visual observations.
Three data sets were evaluated, and these showed some variability in the findings, therefore overall mean values were not generated. The d(0.5) values (the particle size representing the mid-point in each averaged distribution set) were between 507.8 and 731.2 μm. The d(0.1) and d(0.9) values (the particle sizes representing the 10% and 90% points in the distributions) were respectively between 81.2 and 97.9 μm and 1292 and 1444 μm.
It was not possible to calculate overall mean values for the mass median aerodynamic diameter (MMAD) and geometric standard deviation (GSD) values, the three data sets were respectively between 562-810 μm (MMAD), and 46.4-102.9 μm (GSD).
The data distribution tables (considering all data sets) indicate that the mean proportion of test substance found below 10 μm (actual value 10.00 μm) was nil, that below nominally 50 μm (actual value 52.5 μm) was less than 1%, and that below nominally 100 μm (actual value 104.7 μm) was between 11 and 19%.
Reference
NA
Description of key information
The particle size of L-TEE was determined to be:d(0.1):81.2 – 97.9 μm, d(0.5): 507.8 and 731.2 μm and d(0.9) 1292 and 1444 μm.
Due to the asymmetric nature of the substance an overall mass median aerodynamic diameter and a geometric standard deviation could not be determined.
The data distribution tables (considering all data sets) indicated that the mean proportion of test substance found below 10 μm (actual value 10.00 μm) was nil, that below nominally 50 μm (actual value 52.5 μm) was less than 1%, and that below nominally 100 μm (actual value 104.7 μm) was between 11 and 19%.
Additional information
The particle size of L-TEE was determined by laser diffraction in combination with Mie theory1. A bimodal distribution of size was observed, which was considered to be broadly representative of the “short” and “long” cross-sections of a distinctly cylindrical (“fibrous”) particulate or crystalline nature, and which corresponded to the visual observations. Three data sets were evaluated, and these showed some variability in the findings, therefore overall mean values were not generated.
The d(0.5) values (the particle size representing the mid-point in each averaged distribution set) were between 507.8 and 731.2 μm. The d(0.1) and d(0.9) values (the particle sizes representing the 10% and 90% points in the distributions) were respectively between 81.2 and 97.9 μm and 1292 and 1444 μm.
Because of the asymmetric nature of the test substance particles, and the inherent variability of the measurements, overall mean values for the mass median aerodynamic diameter (MMAD) and geometric standard deviation (GSD) values could not be calculated. Values for the three data sets were respectively between 562 and 810 μm (MMAD), and 46.4 and 102.9 μm (GSD).
The data distribution tables (considering all data sets) indicate that the mean proportion of test substance found below 10 μm (actual value 10.00 μm) was nil, that below nominally 50 μm (actual value 52.5 μm) was less than 1%, and that below nominally 100 μm (actual value 104.7 μm) was between 11 and 19%.
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