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EC number: 941-379-0
CAS number: -
three rabbits had an ocular reaction 1 hour after instillation of the test
material; the score for each animal was 8.0. No
irritation was observed
In a primary eye irritation study, 0.1
mL/eye of undiluted thermocracked kerosine was instilled into the
conjunctival sac of the right eye of three female young adult New
Zealand White rabbits, and their eyelids held together for one minute
after instillation. Observations were made at pre-screening, 1, 24, 48,
and 72 hours. Irritation was scored according to the Draize method.
At pre-screening all animals were free of
ocular lesions. There was no evidence of damage to the cornea or iris
for all animals over all scoring periods. Mild conjunctivae indicators
such as redness, chemosis, and discharge were evident at the one hour
scoring interval, and at no other scoring interval. Fluorescein staining
scores were zero for all study animals over all scoring periods. The
mean cornea, iris, and conjunctivae scores (24, 48, and 72 hours) were
all 0.0. Thermocracked kerosine is not irritating to the eye according
to EU criteria.
This study received a Klimisch score of 1
and is classified as reliable without restrictions because it was
carried out according to EPA OTS 798.4500.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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