Registration Dossier
Registration Dossier
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EC number: 941-379-0 | CAS number: -
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: This study is classified as reliable with restrictions because it is an acceptable and well-documented study report.
- Justification for type of information:
- Read across justification included in Section 13
Cross-reference
- Reason / purpose for cross-reference:
- read-across: supporting information
Reference
- Endpoint:
- acute toxicity: dermal
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: This study is classified as reliable with restrictions because it is an acceptable and well-documented study report.
- Justification for type of information:
- Read across justification included in Section 13
- Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- yes
- Test type:
- other: API procedure
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Type of coverage:
- not specified
- Vehicle:
- other: Undiluted
- Duration of exposure:
- 24 hours
- Doses:
- Single dose of 2000 mg/kg
- No. of animals per sex per dose:
- Four
- Control animals:
- not specified
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The LD50 was greater than 2000 mg/kg.
- Executive summary:
A group of 4 male and 4 female New Zealand White rabbits was tested at a single dose of 2000 mg/kg. The skins of 2 male and 2 female animals were abraded prior to treatment. Animals were observed for 14 days following the 24-hour exposure period. No deaths resulted. At necropsy, irritated skin at the treatment site was noted in one animal, and pitted areas on the kidneys in two animals. The LD50 was greater than 2000 mg/kg
No deaths resulted. At necropsy, irritated skin at the treatment site was noted in one animal, and pitted areas on the kidneys in two animals.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- yes
- Test type:
- other: API procedure
Test material
- Reference substance name:
- Kerosine (petroleum), hydrodesulfurized
- EC Number:
- 265-184-9
- EC Name:
- Kerosine (petroleum), hydrodesulfurized
- Cas Number:
- 64742-81-0
- IUPAC Name:
- Kerosine (petroleum), hydrodesulfurized
- Reference substance name:
- Hydrodesulfurised kerosine
- IUPAC Name:
- Hydrodesulfurised kerosine
- Test material form:
- other: low viscosity liquid hydrocarbon
- Details on test material:
- - Name of test material (as cited in study report): Hydrodesulfurised kerosine, CAS No. 64742-81-0
- Lot/batch No.: API 81-07
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- other: Undiluted
- Duration of exposure:
- 24 hours
- Doses:
- Single dose of 2000 mg/kg
- No. of animals per sex per dose:
- Four
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
Any other information on results incl. tables
No deaths resulted. At necropsy, irritated skin at the treatment site was noted in one animal, and pitted areas on the kidneys in two animals.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The LD50 was greater than 2000 mg/kg.
- Executive summary:
A group of 4 male and 4 female New Zealand White rabbits was tested at a single dose of 2000 mg/kg. The skins of 2 male and 2 female animals were abraded prior to treatment. Animals were observed for 14 days following the 24-hour exposure period. No deaths resulted. At necropsy, irritated skin at the treatment site was noted in one animal, and pitted areas on the kidneys in two animals. The LD50 was greater than 2000 mg/kg
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