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Diss Factsheets

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: This study is classified as reliable with restrictions because it is an acceptable and well-documented study report.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1982
Report date:
1982

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
GLP compliance:
yes
Test type:
other: API procedure

Test material

Constituent 1
Reference substance name:
Kerosine (petroleum), hydrodesulfurized
EC Number:
265-184-9
EC Name:
Kerosine (petroleum), hydrodesulfurized
Cas Number:
64742-81-0
IUPAC Name:
Kerosine (petroleum), hydrodesulfurized
Constituent 2
Reference substance name:
Hydrodesulfurised kerosine
IUPAC Name:
Hydrodesulfurised kerosine
Test material form:
other: low viscosity liquid hydrocarbon
Details on test material:
- Name of test material (as cited in study report): Hydrodesulfurised kerosine, CAS No. 64742-81-0
- Lot/batch No.: API 81-07

Test animals

Species:
rabbit
Strain:
New Zealand White
Sex:
male/female

Administration / exposure

Type of coverage:
not specified
Vehicle:
other: Undiluted
Duration of exposure:
24 hours
Doses:
Single dose of 2000 mg/kg
No. of animals per sex per dose:
Four
Control animals:
not specified

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw

Any other information on results incl. tables

No deaths resulted. At necropsy, irritated skin at the treatment site was noted in one animal, and pitted areas on the kidneys in two animals.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The LD50 was greater than 2000 mg/kg.
Executive summary:

A group of 4 male and 4 female New Zealand White rabbits was tested at a single dose of 2000 mg/kg. The skins of 2 male and 2 female animals were abraded prior to treatment. Animals were observed for 14 days following the 24-hour exposure period. No deaths resulted. At necropsy, irritated skin at the treatment site was noted in one animal, and pitted areas on the kidneys in two animals. The LD50 was greater than 2000 mg/kg

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