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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: This study is classified as reliable without restrictions because it was carried out in a method equivalent/similar to OECD TG 403.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1983
Report date:
1983

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 403 (Acute Inhalation Toxicity)
GLP compliance:
yes
Test type:
standard acute method

Test material

Constituent 1
Reference substance name:
Kerosine (petroleum), hydrodesulfurized
EC Number:
265-184-9
EC Name:
Kerosine (petroleum), hydrodesulfurized
Cas Number:
64742-81-0
IUPAC Name:
Kerosine (petroleum), hydrodesulfurized
Constituent 2
Reference substance name:
Hydrodesulfurised kerosine
IUPAC Name:
Hydrodesulfurised kerosine
Test material form:
other: low viscosity liquid hydrocarbon
Details on test material:
- Name of test material (as cited in study report): Hydrodesulfurised kerosine, CAS 64742-81-0
- Lot/batch No.: API 81-07

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female

Administration / exposure

Route of administration:
inhalation: aerosol
Type of inhalation exposure:
not specified
Vehicle:
air
Details on inhalation exposure:
Exposure comprised of aerosol/vapour mixture.
Duration of exposure:
4 h
Concentrations:
Single 4 hour whole-body exposure to 5.2 mg/L
No. of animals per sex per dose:
Five
Control animals:
no

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LC50
Effect level:
> 5.2 mg/L air
Exp. duration:
4 h

Any other information on results incl. tables

There were no mortalities during the study. The principal pharmacotoxic sign was dyspnoea which was observed on the day of exposure and for some animals up to 6 days after exposure. There was no effect on body weight gains and no treatment-related abnormalities were observed during necropsy or during the histopathological examination of the lungs and tracheas of the exposed animals.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The LC50 was greater than 5.2 mg/L, the only dose tested.
Executive summary:

In an acute inhalation toxicity study, 5 male and 5 female albino Sprague-Dawley rats were exposed to an aerosol/vapour atmosphere of hydrodesulfurised kerosine for 4 hours at a concentration of 5.2 mg/L. All animals were observed during and after the exposure on the day of exposure and daily during a 14-day post-exposure observation period. Animal body weights were recorded just prior to exposure, on days 7 and 14 post-exposure and at death. At termination of the study, all animals were sacrificed and subjected to complete necropsy. Lungs and trachea were evaluated histopathologically. Dyspnea was the principal sign observed on the day of exposure and during the post-exposure period, with matted fur being a result of the aerosol exposure. There were no deaths during the study and no apparent exposure-related effects on the bodyweights. No exposure related histopathological changes were observed. The LC50 was greater than 5.2 mg/L. The test material is not classified according to EU criteria based on no upper limit for the LC50.

This study received a Klimisch score of 1 and is classified as reliable without restrictions because it was carried out in a method equivalent/similar to OECD TG 403.

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