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Toxicological information

Basic toxicokinetics

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Administrative data

Endpoint:
basic toxicokinetics in vivo
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Cross-reference
Reason / purpose for cross-reference:
reference to same study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1994

Materials and methods

Objective of study:
absorption
Test guideline
Qualifier:
no guideline available
GLP compliance:
yes

Test material

Constituent 1
Reference substance name:
most likely 800-20-6
IUPAC Name:
most likely 800-20-6
Test material form:
other: low viscosity liquid hydrocarbon
Details on test material:
Blend of straight run hydrotreated kerosine (30%) and hydrocracked kerosine (70%), spiked with C14 labelled tetradecane and naphthalene
Radiolabelling:
yes

Test animals

Species:
mouse
Strain:
C3H
Sex:
male

Administration / exposure

Route of administration:
dermal
Vehicle:
other: mineral oil
Duration and frequency of treatment / exposure:
96 hour(s)
Doses / concentrations
Remarks:
Doses / Concentrations:
Males: 15 µl undiluted and 60 µl diluted to 25% with mineral oil
No. of animals per sex per dose / concentration:
Males: 5
Control animals:
yes, concurrent vehicle

Results and discussion

Toxicokinetic / pharmacokinetic studies

Details on absorption:
radio labelled tetradecane and naphthalene were absorbed at 5% and 12% respecively from neat kerosine. For a 25% dilution in mineral oil the compartaive absorption was 7 and 14%
Details on distribution in tissues:
radio labelled naphthalene was found inn urine and to a much lesser extent in faeces and tissues.
radio labelled tetradecane was found in expired air and to a lesser extent in urine, faeces and tissues.
Toxicokinetic parametersopen allclose all
Toxicokinetic parameters:
half-life 1st:
Toxicokinetic parameters:
half-life 2nd:
Toxicokinetic parameters:
half-life 3rd:

Any other information on results incl. tables

In the study with dermally applied undiluted test material approximately 5% of the labelled tetradecane and 15% of the labelled naphthalene was absorbed over 96 hours.
In the study with the 25% concentration of test material, approximately
 7% of the labelled tetradecane and 16% of the labelled naphthalene was absorbed over 96 hours.

In the passive inhalation study approximately 2.8% (undiluted test
 material) and 1.8% (25% concentration) of the labelled naphthalene was available.  In contrast, approximately 0.2% of labelled tetradecane in undiluted and diluted test material was absorbed.

These studies demonstrate that dilution of the test material in mineral
 oil did not influence absorption of the radiolabelled "spikes" present.

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): low bioaccumulation potential based on study results
radio labelled tetradecane and naphthalene (as surrogates for aliphaltic and aromatic constituents) were absorbed through the skin following dermal application of kerosine. Excretion was via urine and expired air and there was little evidnec of tissue accumulation.
Executive summary:

Topical application of radiolabelled kerosine (C14 tetradecane and naphthalene) in mice resulted in low levels of dermal uptake. Absorbed material was excreted in urine and expired air and there was little evidence of tissue accumulation.

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