Registration Dossier
Registration Dossier
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EC number: 201-740-9 | CAS number: 87-33-2
Guidance on Safe Use
Guidance on Safe Use
Administrative data
First-aid measures
First aid general principles - Important information
In case of doubt or in the presence of symptoms contact a physician, and show him/her the material safety data sheet. In case of severe symptoms, call your local health care emergency number. Call a poison control center in order to receive toxicological advice for the clinical management of poisoning.
First aid general principles - Inhalation
In the case of respiratory symptoms (cough, dyspnea) move the person to fresh air, place in a semi-seated position, and administer oxygen. Provide artificial respiration if the person is not breathing.
First aid general principles - Skin contact
Flush the skin with copious amounts of water for at least 15 minutes. Consult a physician if there are symptoms of skin irritation and/or pain.
First aid general principles - Eye contact
Remove contact lenses. Flush the eyes, kept open, with copious amounts of running water for at least 15 minutes. Consult a physician, especially if there are symptoms of eye irritation and/or pain.
First aid general principles - Ingestion
Do not administer anything by mouth unless advised to do so by a poison control center. Do not induce emesis. Rinse the mouth and consult a physician.
In case of doubt or in the presence of symptoms contact a physician, and show him/her the material safety data sheet. In case of severe symptoms, call your local health care emergency number. Call a poison control center in order to receive toxicological advice for the clinical management of poisoning.
First aid general principles - Inhalation
In the case of respiratory symptoms (cough, dyspnea) move the person to fresh air, place in a semi-seated position, and administer oxygen. Provide artificial respiration if the person is not breathing.
First aid general principles - Skin contact
Flush the skin with copious amounts of water for at least 15 minutes. Consult a physician if there are symptoms of skin irritation and/or pain.
First aid general principles - Eye contact
Remove contact lenses. Flush the eyes, kept open, with copious amounts of running water for at least 15 minutes. Consult a physician, especially if there are symptoms of eye irritation and/or pain.
First aid general principles - Ingestion
Do not administer anything by mouth unless advised to do so by a poison control center. Do not induce emesis. Rinse the mouth and consult a physician.
Fire-fighting measures
General information
Move all people away and stay upwind of the fire. Do not enter closed rooms without adequate protection.
Suitable extinguishing media
No special estinguishing media is advisable for this substance. Use the standard estinguishing media. In the choice of extinguishing media, consider the other materials involved in the fire.
Extinguishing media which shall not be used for safety reasons
None.
Exposure hazards arising from the substance itself, combustion products, resulting gases.
The substance is explosive. In the case of fire, irritant or toxic fumes may develop from the substance and from the other materials involved in the fire. Carbon monoxide poisoning may occur.
Protective equipment for fire-fighters
Wear self contained breathing apparatus for fire-fighting if necessary.
Move all people away and stay upwind of the fire. Do not enter closed rooms without adequate protection.
Suitable extinguishing media
No special estinguishing media is advisable for this substance. Use the standard estinguishing media. In the choice of extinguishing media, consider the other materials involved in the fire.
Extinguishing media which shall not be used for safety reasons
None.
Exposure hazards arising from the substance itself, combustion products, resulting gases.
The substance is explosive. In the case of fire, irritant or toxic fumes may develop from the substance and from the other materials involved in the fire. Carbon monoxide poisoning may occur.
Protective equipment for fire-fighters
Wear self contained breathing apparatus for fire-fighting if necessary.
Accidental release measures
General measures
In case of spills, minimize dust formation and do not allow the substance entering drains and watercourses.
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment. Avoid breathing vapors, mist or gas. Ensure adequate ventilation.
Remove all sources of unstability.
Environmental precautions
Cover the drains to prevent the product from entering the environment. If the product contaminates rivers, lakes or drains inform local authorities.
Methods and materials for containment and cleaning up
Contain spillage, collect and place it in container for disposal according to local and national regulations
In case of spills, minimize dust formation and do not allow the substance entering drains and watercourses.
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment. Avoid breathing vapors, mist or gas. Ensure adequate ventilation.
Remove all sources of unstability.
Environmental precautions
Cover the drains to prevent the product from entering the environment. If the product contaminates rivers, lakes or drains inform local authorities.
Methods and materials for containment and cleaning up
Contain spillage, collect and place it in container for disposal according to local and national regulations
Handling and storage
Take the necessary measures to avoid human and environmental exposure. Do not inhale dust. Store in original containers or other appropriately labelled, suitable containers in an environment away from heat sources, drains and watercourses. Handling with attention. The storage may be done carefully due to the unstable properties at a room temperature. The substance is stabilised in mixture with at least 60% lactose, mannose, starch or calcium hydrogen phosphate. Alternatively, it is possible to use an acetone-water solution or other organic solvents such as ether, ethyl alcohol and chloroform.
Transport information
Land transport (UN RTDG/ADR/RID)
- UN number:
- 2907
Shipping information
- Proper shipping name and description:
- Isosorbide dinitrate mixture with at least 60% of lactose, mannose, starch or calcium hydrogen phosphate
- Chemical name:
- Isosorbide dinitrate
- Language:
- English
- Labels:
- -
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Marine transport (UN RTDG/IMDG)
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Exposure controls / personal protection
According to the Company internal procedures, the substance is used under strictly controlled condition (SCC) during its whole lifecycle:
(a) the substance is rigorously controlled from its arrival to its use and transformation:
(b) procedural (Standard Operating Procedures for use) and control technologies are used to minimize emission and any resulting exposure;
(c) the substance is handled only by trained and authorized personnel;
(d) in the case of cleaning and maintenance works, special procedures such as equipment washing are applied before the system is opened and entered;
(e) in cases of accident and where waste is generated, there is an Emergency Plan to minimize emissions and the resulting exposure;
(f) substance-handling procedures are well documented and strictly supervised by the site operator.
A periodic environmental monitoring confirms the efficacy of the above practices.
Details about SCC, exposure controls and personal protection are given in the "RMM_details" document which is attached in section 13 of the Registration Dossier.
(a) the substance is rigorously controlled from its arrival to its use and transformation:
(b) procedural (Standard Operating Procedures for use) and control technologies are used to minimize emission and any resulting exposure;
(c) the substance is handled only by trained and authorized personnel;
(d) in the case of cleaning and maintenance works, special procedures such as equipment washing are applied before the system is opened and entered;
(e) in cases of accident and where waste is generated, there is an Emergency Plan to minimize emissions and the resulting exposure;
(f) substance-handling procedures are well documented and strictly supervised by the site operator.
A periodic environmental monitoring confirms the efficacy of the above practices.
Details about SCC, exposure controls and personal protection are given in the "RMM_details" document which is attached in section 13 of the Registration Dossier.
Stability and reactivity
Unstable at room temperature, it is stabilised in mixture with at least 60% lactose, mannose, starch or calcium hydrogen phosphate. Alternatively, it is possible to use an acetone-water solution for storing.
Details about stability and reactivity are given in the "RMM_details" document which is attached in section 13 of the Registration Dossier.
Details about stability and reactivity are given in the "RMM_details" document which is attached in section 13 of the Registration Dossier.
Disposal considerations
For disposal purposes, the substance is considered as special waste. If needed, contact a center authorized to dispose of this type of waste. Do not dispose of the product in the environment.
Disposal procedures are detailed in the "RMM_details" document which is attached in section 13 of the Registration Dossier.
Disposal procedures are detailed in the "RMM_details" document which is attached in section 13 of the Registration Dossier.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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